An unusual case of papillary carcinoma of the thyroid
with cutaneous and breast metastases only.
LiVolsi, "Tall cell papillary carcinoma of the thyroid
: metastatic to the pancreas," Thyroid, vol.
Han et al., "Diffuse sclerosing variant of papillary carcinoma of the thyroid
: imaging and cytologic findings," Thyroid, vol.
Studies have shown absence of the RET and BRAF mutations that are seen in papillary carcinoma of the thyroid
. (154-157) Molecular analysis has shown the presence of a missense point mutation in PIK3CA in many of these lesions, similar to the mutations encountered in invasive ductal carcinoma NST.
A moderate degree of nuclear atypia was also observed, but all specimens also contained areas of typical nuclear enlargement with crowding and overlapping, prominent nuclear grooves, occasional intranuclear pseudoinclusions, and foci of optical cleating of nuclei typical of papillary carcinoma of the thyroid
. The surrounding parenchyma in 4 of the 5 specimens contained a chronic lymphocytic infiltrate in the pattern typical of Hashimoto's thyroiditis, a finding that was consistent with the clinical diagnosis in these patients.
For example, large, optically clear nuclei, so-called "orphan Annie" nuclei, are often found in papillary carcinoma of the thyroid
. (11) This change is present in sections obtained from paraffin-embedded material and the mechanism of its formation has not yet been ascertained.
The patient had a history of papillary carcinoma of the thyroid
, which had been treated with thyroidectomy 2 years earlier.
"Occult papillary carcinoma of the thyroid
. A 'normal' finding in Finland.
Papillary carcinoma of the thyroid
: a clinicopathologic study of 241 cases treated at the University of Florence, Italy.
* In young patients with papillary carcinoma of the thyroid
, most cases of recurrence are attributable to regional lymph node flare-ups.
Fine needle aspiration cytology of follicular variant of papillary carcinoma of the thyroid
: Morphologic pointers to its diagnosis.
FNAB indicated papillary carcinoma of the thyroid
in 31 patients, 26 of whom (83.9%) did indeed have cancer.