papaverine


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papaverine

 [pah-pav´er-in]
an alkaloid obtained from opium or prepared synthetically; the hydrochloride salt has been used as a smooth muscle relaxant and vasodilator to relieve arterial spasms causing cerebral, peripheral, or myocardial ischemia and is also injected into the penis in the diagnosis and treatment of erectile dysfunction.

pa·pav·er·ine

(pă-pav'ĕr-ēn),
A nonnarcotic benzylisoquinoline alkaloid of opium that has mild analgesic action and is a powerful spasmolytic; has been used to treat male impotence by local injection, which works by inhibiting phosphodiesterase in smooth muscle cells. Also available as papaverine hydrochloride.
[L. papaver, poppy]

papaverine

(pə-păv′ə-rēn′, -ər-ĭn)
n.
A nonnarcotic alkaloid obtained from the opium poppy, C20H21NO4, structurally distinct from morphine and other opiates, used in its hydrochloride form to relieve spasms of smooth muscle.

pa·pav·er·ine

(pă-pav'ĕr-ēn)
A nonnarcotic benzylisoquinoline alkaloid of opium that has mild analgesic action and is a powerful spasmolytic.
[L. papaver, poppy]

papaverine

An opium derivative used as a smooth muscle relaxant and to treat heart irregularities following a heart attack. Papaverine has been used to treat organic impotence by direct injection into the corpora cavernosa of the penis.

Papaverine

A smooth muscle relaxant sometimes injected into the penis as a treatment for impotence.
Mentioned in: Impotence

pa·pav·er·ine

(pă-pav'ĕr-ēn)
Mild analgesic and powerful spasmolytic.
[L. papaver, poppy]
References in periodicals archive ?
These patients had some delayed response to injection papaverine, but did not reveal arterial or venous insufficiency.
The evaluated extracts were neither more powerful nor more effective than Papaverine (phosphodiesterase inhibitor), used as positive control ([E.sub.max] = 95%).
However, the rate of papaverine hydrochloride degradation processes is enhanced as a function of oxygen pressure.
Attenuation of the no-reflow phenomenon after coronary angioplasty for acute myocardial infarction with intracoronary papaverine. Am Heart J.
The functional diagnostic parameter FFR is performed with 0.014 inch diameter intracoronary pressure wire to record the distal pressure under hyperemic condition, which is induced by microvascular vasodilator, adenosine, or papaverine [6].
The inhibitory effects of cinnarizine on the noradrenaline and Ca-induced contraction of the rabbit thoracic aorta and mesenteric arteries were compared to papaverine [14].
At the end of each dose response curve for acetylcholine or calcitonin gene-related peptide papaverine ([10.sup.-5] M) was added to determine maximal vasodilation.
Constantinou, "Effects of [1-desamino-8D-arginine]vasopressin and papaverine on rabbit renal pelvis," European Journal of Pharmacology, vol.
Several internal standards are described in the literature such as papaverine hydrochloride (Allanson et al., 2007), p-dimethyl (Chan, 1986), rifapentine (Panchagnula et al., 1999) and sulindac (Lau et al., 1996).
Papaverine, calcium antagonists (nimodipine, nicardipine or verapamil) and milrinone (46,47) are effective in reversing cerebral vasospasm to varying extents (48) but repeat treatments are frequently required.
Thin layer chromatography of Opium Alkaloids with hybrid CTAB-AlcoholWater mobile phase and estimation of papaverine. HCl and codeine sulphate in pharmaceutical formulations.
Drug interactions with hawthorn are worth paying attention to, with some reports that it can potentiate the effects of cardiac glycosides, potentiate barbiturate-induced sleeping times, and increase the coronary-artery dilating effect induced by theophylline, epinephrine, adenosine, papaverine, and caffeine.22-24