pantothenate synthetase

pan·to·then·ate syn·the·tase

an enzyme that converts pantoate and β-alanine to pantothenate with concomitant cleavage of ATP to AMP and pyrophosphate; a key step in coenzyme A biosynthesis.
References in periodicals archive ?
Development of 3-phenyl-4567-tetrahydro-1H-pyrazolo[43-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors.
Pantothenate synthetase (MfPS; EC 6.3.2.1) catalyzes the essential adenosine triphosphate-dependent condensation of D-pantoate and [beta]-alanine to form pantothenate in bacteria, yeast, and plants.
Mycobacterial Pantothenate Synthetase (MtPS) Screening [20, 21].
Ross et al., "A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase," Journal of Biomolecular Screening, vol.
Liu et al., "A discovery of novel Mycobacterium tuberculosis pantothenate synthetase inhibitors based on the molecular mechanism of actinomycin D inhibition," Bioorganic and Medicinal Chemistry Letters, vol.
Sriram, "Development of 3-phenyl-4,5,6,7-tetrahydro-1Hpyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors," European Journal of Medicinal Chemistry, vol.