panlobular emphysema


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pan·lob·u·lar em·phy·se·ma

emphysema affecting all parts of the secondary pulmonary lobule, typically involving the inferior part of the lung and often asociated with a α1-antitrypsin deficiency.

panlobular emphysema

Pulmonology Emphysema that is more common in ♀, of relatively early onset–usually in the 4th decade, often associated with alpha-1-antitrypsin deficiency; bronchitis may develop in late-stage disease. See Chronic bronchitis, Emphysema.

pan·lob·u·lar em·phy·se·ma

(pan-lōb'yū-lăr em'fi-sē'mă)
Emphysema affecting all parts of the lobules, in part, or usually the whole, of the lungs, and usually associated with α1-antiprotease deficiency emphysema.
References in periodicals archive ?
Pistolesi et al., "Physiologic and quantitative computed tomography differences between centrilobular and panlobular emphysema in COPD," Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, vol.
Maisel, "Are centrilobular emphysema and panlobular emphysema two different diseases?" Human Pathology, vol.
In addition to the 78 patients from the lung cancer prevention study, the researchers collected data on four deceased patients who each donated a lung for transplantation (controls), four patients with centrilobular emphysema who each donated a lung, and eight patients with panlobular emphysema who donated 10 lungs after lung transplantation.
Plasma deficiency of AAT is most commonly due to the Z mutation (Glu342 GAG [right arrow] Lys AAG) and is associated with early-onset panlobular emphysema. Reduced AAT levels (~ 10-15 % of normal) result in a compromised "protective screen" of antiprotease activity.