The addition of lower-lung-predominant panlobular
emphysma suggests methylphenidate (Ritalin) abuse associated with intravenous talcosis.
13,14) Macrovesicular steatosis is most often centrilobular, though it may become panlobular
when more than two-thirds of the parenchyma is affected.
Patterns of centrolobular, hydropic, granular (2 dpi), centrolobular (3 dpi), and panlobular
(4 dpi) microvesicular fatty degeneration were also observed in the livers of all subtype H5N1-infected animals.
The picture was quite different from the panlobular
microvesicular steatosis of Reye's syndrome (22) or that of viral hepatitis or infectious diseases involving the liver, such as melioidosis, typhoid fever or malaria.
Typically in mammalian liver, CYP1A1 expression is localized to periportal parenchyma in untreated or slightly induced animals, and panlobular
expression is seen only in animals in which CYP1A1 is strongly induced (Oinonen and Lindros 1998).
emphysema in young intravenous Ritalin abusers.
Plasma deficiency of AAT is most commonly due to the Z mutation (Glu342 GAG [right arrow] Lys AAG) and is associated with early-onset panlobular
1999; International Life Sciences Institute 1997; and this report) found necrosis ranging from single-cell necrosis to small clusters of necrotic hepatocytes, and to occasional panlobular
coagulative necrosis in mice receiving 1.