Cigarette smoking can result in either panlobular
emphysema (PLE) or centrilobular emphysema (CLE), and the latter shows worse remodeling and narrowing of small airways, which can result in the airflow obstruction similar to asthma.
D-GaIN caused panlobular
focal necrosis and periportal inflammation, which was accompanied by an inflammatory infiltrate of predominantly polymorph nuclear cells with a few lymphocytes and swollen macrophages (Robert et al.
A, Gross photograph of a lung lobule with panlobular
Typical findings of small centrilobular, subpleural nodules, and heterogeneous conglomerate masses containing high-density amorphous areas, with or without panlobular
emphysema in the lower lobes, are highly suggestive of pulmonary talcosis [6, 7].
However, we also found that, even in the advanced stages of liver fibrosis in which the incidence of positive FVIIIRAg staining is higher, the immunostaining of sinusoidal endothelium is not diffusely panlobular
but is characteristically patchy and discontinuous along the sinusoidal lining.
Enfisema centrolobular (centroacinar) e panlobular
The addition of lower-lung-predominant panlobular
emphysma suggests methylphenidate (Ritalin) abuse associated with intravenous talcosis.
The findings "extend earlier reports by showing that there is both widespread narrowing and loss of smaller conducting airways before the onset of emphysematous destruction in both centrilobular and panlobular
emphysema phenotypes of COPD," Mr.
Patterns of centrolobular, hydropic, granular (2 dpi), centrolobular (3 dpi), and panlobular
(4 dpi) microvesicular fatty degeneration were also observed in the livers of all subtype H5N1-infected animals.
As alteracoes histologicas incluem necrose hepatica centrolobular a panlobular
, associadas a inclusoes intranucleares basofilicas caracteristicas, que aparecem inicialmente em celulas de Kupffer e apos em hepatocitos viaveis ou degenerados adjacentes a areas de necrose (GREENE, 2006).
The picture was quite different from the panlobular
microvesicular steatosis of Reye's syndrome (22) or that of viral hepatitis or infectious diseases involving the liver, such as melioidosis, typhoid fever or malaria.
Typically in mammalian liver, CYP1A1 expression is localized to periportal parenchyma in untreated or slightly induced animals, and panlobular
expression is seen only in animals in which CYP1A1 is strongly induced (Oinonen and Lindros 1998).