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Related to panhypopituitarism: diabetes insipidus


generalized hypopituitarism due to absence of or damage to the pituitary gland; in its complete form it leads to absence of gonadal function, loss of secondary sex characters, and insufficiency of thyroid and adrenal function. When cachexia is a prominent feature, it is called simmonds' disease.

pan·hy·po·pi·tu·i·tar·ism (PHP),

(pan-hī'pō-pi-tū'i-tăr-izm), [MIM*312000]
A state in which the secretion of all anterior pituitary hormones is inadequate or absent; caused by a variety of disorders that result in destruction or loss of function of all or most of the anterior pituitary gland. Rare forms of PHP are inherited as autosomal recessive [MIM*262600] or as X-linked recessive [MIM*312000].

Sheehan syndrome

A condition that follows postpartum uterine haemorrhage severe enough to cause circulatory collapse, resulting in pituitary necrosis and hypopituitarism, especially if disseminated intravascular coagulation (DIC) was also present.

Clinical findings
Galactorrhoea, amenorrhoea or oligomenorrhoea, secondary hypothyroidism, cold intolerance, hypotension, bradycardia, weight gain, hair loss, adrenal insufficiency, fatigue, loss of libido, hypoglycaemia, hyponatraemia.


Pituitary dwarfism, see there.


(PHP) (pan-hī'pō-pi-tū'i-tă-rizm)
A state in which the secretion of all anterior pituitary hormones is inadequate or absent.
Synonym(s): hypophysial cachexia.


Generalized decrease of all of the anterior pituitary hormones.
Mentioned in: Pituitary Dwarfism


(pan-hī'pō-pi-tū'i-tă-rizm) [MIM*312000]
A state in which secretion of all anterior pituitary hormones is diminished.
Synonym(s): hypophysial cachexia.
References in periodicals archive ?
Primary CNS lymphoma with bilateral symmetric hypothalamic lesions presenting with panhypopituitarism and diabetes insipidus.
Notable complications following radiation therapy for JNA reported in the literature include panhypopituitarism, posterior capsular opacification, temporal lobe necrosis, growth retardation, and radiation keratopathy [5].
The hormonal deficiencies were analyzed at the moment of the diagnosis and in the last check-up, and this analysis found the following proportions: for hypothyroidism, 86.7% versus 92% (p = 0.001); for hypocortisolism, 62% versus 78% (p = 0.001); for hypogonadism, 67% versus 76% (p = 0.001); for hyposomatotropism, 89% versus 94% (p = 0.002); and for panhypopituitarism, 67.8% versus 78% (p = 0.001) (Table 1).
Paul's Panhypopituitarism was caused by a birth defect which left him with a piece of his skull missing.
In this report, we discuss an interesting case of an infant who presented with a seizure after birth and was later found to have panhypopituitarism with an absence of pituitary gland, situs inversus, and left ureterocele with hydronephrosis.
Panhypopituitarism (hyposecretion of 3 or more of pituitary produced hormones) is one of the possible presentations.
Clinical manifestations depend on the direction of the expansion toward adjacent structures and include frontoorbital headache (87%); amaurosis (58%); oculomotor palsies (55%); nasal symptoms (38%) that include anosmia, nasal obstruction, hypoacusis, and nasal discharge [8]; endocrine disorders (3%); and panhypopituitarism (0.8%) [2].
Rodriguez Senchez, "Congenital panhypopituitarism as part of the solitary median incisor syndrome," Anales de Pediatria, vol.
He obtained significant tumor debulking, resulting in a panhypopituitarism including diabetes insipidus for which he was treated with desmopressin in a fixed daily dosage scheme and a strict control of intravenous/enteral fluids.
The neurological symptoms, in lowering order of frequency, are diabetes insipidus, exophthalmos, cerebellar ataxia, panhypopituitarism, and papilledema which correlate with the various radiological finding [11, 12].
reported on the association between endocrine disorders and valgus SCFE, 2 patients with underdeveloped genitalia and 1 with panhypopituitarism in a series of 7 patients with valgus patients [4].