panel reactive antibody


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panel reactive antibody

Abbreviation: PRA
A measure of an organ transplant recipient's level of sensitization to antigens on donated organs. It is the percentage of cells taken from a broad selection of blood donors against whose antigens the organ recipient's serum reacts. The higher the panel reactive antibody, the more challenging it is to match a donor organ to the recipient.
See also: antibody
References in periodicals archive ?
Percent panel reactive antibody taken at various time points (A: at time of graft failure, B: 6 months after graft failure/allograft nephrectomy, and C: last follow-up) in patients who received late allograft nephrectomy (>6 months post transplant, black circles) and those who were maintained on immunosuppression despite late graft failure (>6 months post transplant, black squares).
Change in percent panel reactive antibody from time of graft failure to time of last follow-up in various immunosuppression withdrawal protocols.
It includes: 1) not performing a screening crossmatch; 2) immediate transplantation for recipients with a 0% panel reactive antibody (PRA), provided they have not had any interim transfusions and the operating room is ready before crossmatch completion; and 3) a final crossmatch performed posttransplantation.