In addition to pancreatitis, FCS patients are at risk of chronic complications due to permanent organ damage, including chronic pancreatitis and pancreatogenic
(type 3c) diabetes.
The exclusion criteria were the presence of pancreatogenic
diabetes (type 3c diabetes), hepatic diabetes, gestational diabetes, secondary diabetes from endocrine disease or type 1 diabetes; ongoing hemodialysis; current malignant, inflammatory disease or chronic respiratory disease; age-related macular degeneration; glaucoma; retinal diseases other than DR; and a history of intraocular surgery.
"This lack of specificity suggests that either the increased pancreatitis risk is related to newly diagnosed and drug-treated type 2 diabetes per se, with a possibility of reverse causality due to pancreatogenic
diabetes," or that starting therapy with sulfonylureas and insulin "also causes acute pancreatitis, which should be further investigated," they said.
Although the quality of life is significantly improved in many patients, only about 1/3 of them become insulin independent, 1/3 require minimal insulin replacement (<10 u/day), and the rest develop pancreatogenic
diabetes after surgery due to low islet cell survival .