pancreatic polypeptide

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pan·cre·at·ic pol·y·pep·tide

1. a 36-amino acid peptide secreted by islet cells of the pancreas in response to a meal and of uncertain physiologic function;
2. a family of gastrointestinal peptides, which includes pancreatic polypeptide, neuropeptide Y, and peptide YY.


pertaining to the pancreas. See also pancreatitis, diabetes mellitus, cystic pancreatic duct.

pancreatic abscess
occurs as a complication of acute pancreatitis or subsequent to pancreatic surgery due to bacterial contamination but is most common as an extension from a leaking gastric ulcer.
pancreatic acinar atrophy
the islets of Langerhans remain normal but acinar tissue atrophies and exocrine function is compromised. Seen most commonly in large breeds of dogs, particularly German shepherd dogs. Clinical signs are related to the exocrine pancreatic insufficiency (see below).
acute pancreatic necrosis
see acute hemorrhagic pancreatitis.
alpha cells cells in the islet of Langerhans which secrete glucagon.
pancreatic anomaly
includes acinar hypoplasia and congenital Islet of langerhans aplasia.
beta cells comprise the majority of pancreatic islet cell population; secrete insulin.
pancreatic bladder
a diverticulum in the pancreatic duct like a gallbladder in the bile duct. Seen in some cats.
pancreatic C-cells
cells in the islet of Langerhans with no known function.
pancreatic calculus
small concretions, 4 to 5 mm diameter, in the pancreatic ducts, caused by chronic inflammation. Seen, usually in large numbers, in cattle.
pancreatic cysts
anomalous obstructions of ducts, often associated with similar cysts in kidneys and bile ducts.
pancreatic delta cells
cells in the islet of Langerhans; known to secrete somatostatin, and vasoactive intestinal peptide.
pancreatic duct
one of the two excretory ducts of the pancreas. Depending on the species, it may unite with the common bile duct before entering the duodenum at the major duodenal papilla. Absent from the pig and ox which only have an accessory pancreatic duct (developed from the dorsal primordium) which opens on the minor duodenal papilla. See also bile duct.
pancreatic duct obstruction
congenitally by agenesis of the duct, by pancreatic lithiasis or inflammation; causes initial distention followed by atrophy of acinar tissue.
pancreatic ectopic tissue
small masses of pancreatic exocrine or endocrine tissue found occasionally in the wall of the stomach or intestines and in the gallbladder; presumed to be functional.
pancreatic enzymes
the exocrine secretion into the intestine includes amylase, endo- and exopeptidases, and lipase. The endopeptidases include trypsin, chymotrypsin and elastase, the exopeptidases are the carboxypeptidases A and B.
exocrine pancreatic insufficiency
insufficient secretion of digestive enzymes, usually due to loss of acinar tissue from idiopathic atrophy or acute or chronic inflammation, causes maldigestion and malabsorption with diarrhea, steatorrhea and weight loss.
pancreatic fibrosis
a sequel to pancreatitis, pancreatic duct obstruction, zinc poisoning.
pancreatic fluke
pancreatic gastrinoma
a gastrin-producing tumor arising from the delta cells of the pancreatic islets that causes hypergastrinemia, hypersecretion of gastric acid and ulceration of the upper gastrointestinal tract. Occurs rarely in dogs. See also zollinger-ellison syndrome.
pancreatic hypertrophy
physiological response to diets high in protein and energy.
pancreatic islets
islets of cells scattered through the pancreas; contain alpha, beta, C and D cells.
pancreatic islet cell tumor
pancreatic lipase
enzyme released from the exocrine pancreas; catalyzes the hydrolysis of dietary lipids in the presence of bile salts. See also lipase.
pancreatic lithiasis
see pancreatic calculus (above).
pancreatic nodular hyperplasia
hard, pale elevations on the surface of the gland; involve only the exocrine tissue; common in old cats and dogs; cause unknown; no discernible effect on patient.
pancreatic polypeptide
secreted by the pancreas into the blood but has no apparent function.
pancreatic trypsin inhibitor
see trypsin inhibitor.
References in periodicals archive ?
5 [A], X40 [B and E], and X20 [C and D]; Pancreatic polypeptide, inhibin, and tyrosine hydroxylase, original magnifications, X20[ F, G, and H]).
2 + - - CA 19-9 + - - CEA + - - Insulin - - + Glucagon - - + Somatostatin - - + PP - - + Synaptophysin - + + * IPMH indicates intraductal papillary mucinous hyperplasia; ICT, islet cell tumor; CEA, carcinoembryonic antigen; and PP, pancreatic polypeptide.
Immunoreactivity for pancreatic polypeptide and somatostatin stains was negative.
7] In the cases reported to date, the consistent localization of the GP along the route traveled by the ventral pancreatic primordium as it rotates around the duodenum, coupled with its reactivity for pancreatic polypeptide, was the basis for the postulated pancreatic origin of this lesion.
Immunoreactivity for pancreatic polypeptide in the majority of GPs is a feature considered supportive of their pancreatic origin; however, immunoreactivity of pancreatic polypeptide is not specific for pancreatic endocrine phenotype.
2 Prediluted Epithelial membrane antigen 1:50 Carcinoembryonic antigen 1:50 Vimentin Prediluted Desmin Prediluted S100 1:50 Chromogranin 1:50 Leu-7 Prediluted Somatostatin 1:200 Gastrin 1:300 Serotonin 1:200 Adrenocorticotropic hormone 1:500 Pancreatic polypeptide 1:750 Vasoactive intestinal peptide 1:1500 Calcitonin 1:150 Antibody Source AE 1/AE Boehringer Mannheim, Indianapolis, Ind CAM 5.
No reactivity was detected with antibodies against desmin, gastrin, serotonin, adrenocorticotropic hormone, pancreatic polypeptide, and vasoactive intestinal peptide.