pancreatic insufficiency

pan·cre·at·ic ste·a·tor·rhe·a

steatorrhea due to the absence of pancreatic juice from the intestine.

pancreatic insufficiency

a condition characterized by inadequate production and secretion of pancreatic hormones or enzymes. It usually occurs secondary to a disease process destructive to pancreatic tissue. Nutritional malabsorption, anorexia, poorly localized upper abdominal or epigastric pain, malaise, and severe weight loss often occur. Alcohol-induced pancreatitis is the most common form of the condition. Supportive care, specific treatment of the cause, and replacement or augmentation of the absent or lacking substances are usually recommended as therapy for pancreatic insufficiency.

pancreatic insufficiency

A relative or absolute lack of pancreatic enzymes, a finding typical of cystic fibrosis. See Cystic fibrosis.
References in periodicals archive ?
Anthera Pharmaceuticals announced that Sollpura did not meet the non-inferiority margin of the CFA primary endpoint in the RESULT Phase 3 clinical study of exocrine pancreatic insufficiency, or EPI, due to cystic fibrosis.
Alcresta Therapeutics completed a multicenter, randomized, double-blind, placebo-controlled crossover clinical study in adult and pediatric patients with CF receiving enteral feeding, the purpose of which was to evaluate the safety, tolerability (evaluated through analysis of gastrointestinal symptoms and select activities of daily living), and fat absorption with use of Relizorb as a part of the enteral feeding circuit in patients with CF who have confirmed exocrine pancreatic insufficiency.
Pre-LTX and post-LTX, individuals with CF are at high risk for low bone mineral density (BMD) related to chronic use of corticosteroid and other immunosuppressive therapy (such as tacrolimus), antibiotic use and chronic undernutrition secondary to poor intake, increased energy expenditure, and pancreatic insufficiency [2-4].
com)-- Exocrine Pancreatic Insufficiency Diagnostics Market 2013-2020 report estimates the global exocrine pancreatic insufficiency diagnostics market to reach nearly USD 2.
M2 EQUITYBITES-May 2, 2016-Allergan announces positive opinion for the marketing authorisation of ENZEPI (pancrelipase) for exocrine pancreatic insufficiency (EPI) in the EU
This article focuses on pharmacologic therapies used to manage two of the most common maldigestion problems: exocrine pancreatic insufficiency and lactose intolerance.
It is this impairment of chloride ion transport that leads to the classic phenotypic features of CF (eg, pulmonary function decline, pancreatic insufficiency, malnutrition, chronic respiratory infection), and is the target of both established and emerging therapies (3)--both of which I will review here.
Although reported in literature, pancreatic resection is associated with a higher incidence of complications as pancreatitis, pancreatic fistulae and pancreatic insufficiency.
Most were women and showed exogenous pancreatic insufficiency (EPI).
USPRwire, Sun Oct 18 2015] Global Markets Direct's, 'Exocrine Pancreatic Insufficiency - Pipeline Review, H2 2015', provides an overview of the Exocrine Pancreatic Insufficiency's therapeutic pipeline.
In chronic pancreatitis patients with exocrine pancreatic insufficiency, the duodenal pH is persistently low.
It's associated with pancreatic insufficiency, liver dysfunction, requirement for corticosteroids, and prognostically with under nutrition, worse pulmonary function, and early death, noted Dr.