Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis
. Gut, 55(1):79-89, 2006.
Apte, "Vitamin A inhibits pancreatic stellate cell activation: implications fortreatment of pancreatic fibrosis," Gut, vol.
Bell Jr., "Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis," Journal of Surgical Research, vol.
One of the key features in the microscopic examination of alcoholic CP is pancreatic fibrosis
. Decisive advances in our understanding of pancreatic fibrosis
have been made by the ability to isolate and culture PSCs (Apte et al.
Vollmar, "Diabetes increases pancreatic fibrosis
during chronic inflammation," Experimental Biology and Medicine.
Diffuse pancreatic fibrosis
: an uncommon feature of multifocal idiopathic fibrosclerosis.
The most common cause of chronic pancreatitis is long-term alcohol abuse. According to our previous study, pancreatic fibrosis
associated with alcohol abuse can show any fibrosis pattern according to Martin's 3 main patterns of pancreatic fibroatrophic states: (1) predominantly intralobular sclerosis, which is always homogenous and diffuse; (2) predominantly perilobular sclerosis, with a cirrhosis-like aspect but which is irregular and sometimes patchy; and (3) mixed intralobular and perilobular sclerosis, often homogenously distributed in the gland.