Simeon Springer, Ph.D., from Johns Hopkins University in Baltimore, and colleagues used supervised machine learning techniques to develop a comprehensive test, CompCyst, to guide management of pancreatic cysts
. The test was based on clinical and imaging features and cyst fluid genetic and biochemical markers.
That is the big question for hundreds of thousands of Americans diagnosed each year with a pancreatic cyst
With the improved sensitivity and decreasing costs of DNA sequencing technology, pathologists have begun to apply fluid-based mutational analyses to the diagnosis of pancreatic cysts
. Because mutations in certain alleles show strong correlation with the phenotype of pancreatic cysts
, analysis of DNA within cyst fluid for these pathognomonic mutations can aid in preoperative diagnosis.
Characteristics of the study group Clinicopathological features Frequency n (%) Sex Male 35 (50%) Female 35 (50%) Age <60 years 33 (47.2%) [greater than or equal to]60 years 37 (52.8%) Diagnosis pancreatitis 23 (32.9%) pancreatic ductal adenocarcinoma 38 (54.3%) pancreatic cysts
9 (12.8%) Location head 33 (47.1%) body 5 (7.1%) tail 20 (28.6%) body and tail 12 (17.2%) Table 2.
American Gastroenterological Association guidelines are inaccurate in detecting pancreatic cysts
with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data.
Song et al., "Endoscopic ultrasonography-guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts
," Gastroenterology, vol.
In addition, Von Hippel Lindau disease is a rare autosomal-dominant genetic disorder with variable penetrance which is characterized by hemangioblastomas in brain, spinal cord and retina, pheochromocytomas, and multiple renal and pancreatic cysts
with an increased risk of malignant transformation.
Abdominal ultrasonography revealed large pancreatic cysts
. The diagnosis of a pancreatic pseudocyst was made, and ultrasound-guided puncture drainage was performed.
They are further subdivided into bronchogenic, esophageal, gastric, enteric, and pancreatic cysts
American Gastroenterological Association Institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts
It may present with hemangioblastomas in the brain, spinal cord, and retina; renal cysts and clear cell renal cell carcinoma; pheochromocytoma; pancreatic cysts
and neuroendocrine tumors; endolymphatic sac tumors; and epididymal and ligamentum latum cysts.