One might classify these diseases according to whether the histologic patterns, along with clinical and radiologic correlation, show changes diagnostic of a particular disease; however, except for diffuse idiopathic neuroendocrine cell hyperplasia and diffuse panbronchiolitis, and arguably follicular bronchiolitis and respiratory bronchiolitis-interstitial lung disease, the histologic changes, such as cellular bronchiolitis and fibrotic changes, are typically not specific for a distinctive etiology.
95-99) One patient with a prior diagnosis of diffuse panbronchiolitis and worsening symptoms despite therapy subsequently was diagnosed as having eosinophilic bronchiolitis.
29,100-126) The term diffuse panbronchiolitis refers to its distribution in both lungs (diffuse) and the inflammatory involvement of all layers of the wall or respiratory bronchioles (pan).
Although uncommon conditions such as diffuse idiopathic neuroendocrine cell hyperplasia and diffuse panbronchiolitis have histologic features that allow for relatively specific diagnoses, and although some conditions such as mineral dust-associated small airways disease, RBILD, granulomatous bronchiolitis, eosinophilic bronchiolitis, and fol licular bronchiolitis have histologic features that may be diagnostic in the appropriate clinical and radiologic setting, most cellular and fibrotic changes found in small airways disease are nonspecific.
Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis.
Diffuse panbronchiolitis in North America: report of three cases and review of the literature.
42) Recurrence of the primary disease has been described with many conditions, including sarcoidosis, lymphangioleiomyomatosis, Langerhans cell histiocytosis, talc granulomatosis, diffuse panbronchiolitis
, and alveolar proteinosis.