The liver had a panacinar
acute hepatocellular swelling and multiple small foci (3 to 40 cells) of coagulative necrosis of hepatocyte located in zone 3 and periacinar zone.
Emphysema may be classified into various types, based on the pattern of lung parenchyma destruction with respect to the secondary pulmonary lobule: proximal acinus in centriacinar (centrilobular) emphysema and distal in paraseptal and whole acinus in panacinar
 In the aged lungs, the alveoli are enlarged and there is a mild degree of panacinar
emphysema which causes air trapping in aged lungs.
In 1952, Gough (5) used paper-mounted sections to describe what he termed "fundamentally different" types of emphysema, types that we now know as centriacinar (centrilobular) and panacinar
An autopsy showed hepatic panacinar
necrosis, erythrophagocytosis of Kupffer cells, and severe decrease of splenic lymphoid tissue (functional asplenia) with multiple drepanocytes and splenic sequestration, but no signs of yellow fever or malaria (online Technical Appendix Figure, http://wwwnc.cdc.gov/EID/article/22/5/15-1934-Techapp1.pdf).
Steatosis is considered more severe as it progresses outward from the centrilobular region to zone 1, and it was apparent in all mice, but lipid accumulation was more panacinar
in in utero [As.sup.III] exposed groups (Figure 2B,C), whereas it was more limited to zones 3 and 2 in control and PN animals (Figure 2A,D).
* Three types centriacinar, panacinar
, and distal acinar
Histological examination of tissue slides of the liver showed diffuse panacinar
steatosis with feathery degeneration of the hepatocytes and ballooning in areas (Fig.
Specifically, the scores were as follows: steatosis: 0 = none; 1 = up to 33% of acini, mainly macrovesicular; 2 = 34-66% of acini, commonly mixed steatosis; 3 = over 66% of acini (panacinar
), commonly mixed steatosis; hepatocyte ballooning: 0 = none; 1 = occasional in zone III; 2 = obvious in zone III; 3 = marked, predominantly in zone III; lobular inflammation: 0 = none; 1 = scattered neutrophils, occasional mononuclear cells, 1 or 2 foci per 20x objective; 2 = neutrophils associated with ballooned hepatocytes, mild chronic inflammation, 3 or 4 foci per 20x objective; 3 = acute and chronic inflammation, neutrophils possibly concentrated in zone III, over 4 foci per 20x objective.
A teoria elastase-antielastase permite justificar o enfisema do tipo panacinar
, que e o que ocorre preferencialmente nos pacientes com deficiencia de alfa-1 antiprotease.
A high resolution computed tomography of the chest demonstrated severe centrilobular and panacinar