palmoplantar keratoderma


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keratoderma

 [ker″ah-to-der´mah]
hypertrophy of the horny layer of the skin.
keratoderma blennorrha´gicum a cutaneous manifestation of reiter's disease, most often involving the palms, soles, toes, and glans penis, and characterized by development of thick keratotic coverings; the lesions resemble those of pustular psoriasis. The disorder was formerly thought to be associated with gonorrhea.
keratoderma climacte´ricum an acquired form of keratoderma that affects the palms of the hands and soles of the feet; it occurs in women about the time of menopause and may be associated with fissuring of the thickened patches.
palmoplantar keratoderma a group of mostly inherited disorders characterized by the excessive formation of keratin, localized or diffuse, on the palms and soles, sometimes with painful lesions resulting from fissuring of the skin; it may occur alone or may accompany or be part of another disease.

pal·mo·plan·tar ker·a·to·der·ma

[MIM*148600 & MIM*244850]
the occurrence of symmetric diffuse or patchy areas of hypertrophy of the horny layer of the epidermis on the palms and soles; a group of ectodermal dysplasias of considerable variety, and either autosomal dominant or recessive inheritance.

palmoplantar keratoderma

; PPK rare, inherited group of skin diseases characterized by altered keratin formation; presents variably as diffuse, focal or punctate palmar and plantar hyperkeratosis, e.g. of weight-bearing skin; severe forms are associated with constricting digital bands, leading to autoamputation; treated by regular hyperkeratosis reduction, keratolytic ointments (e.g. 5-10% salicylic acid in white soft paraffin) and oral retinoids (i.e. vitamin A-derivative) drugs

pal·mo·plan·tar ker·a·to·der·ma

(palmō-plantăr keră-tō-dĕrmă) [MIM*148600 & 244850, MIM*148600, MIM*244850, MIM*148600 &]
Symmetric diffuse or patchy areas of hypertrophy of horny layer of epidermis on the palms and soles.
References in periodicals archive ?
Epidermolytic palmoplantar keratoderma of Varner: re-evaluation of Varner's original family and identification of a novel keratin 9 mutation.
Psoriasis and hereditary palmoplantar keratoderma complicated with a dermatophyte infection.
Hereditary epidermolytic palmoplantar keratoderma (Vorner type) in a family with Ehlers-Danlos syndrome.
Inherited palmoplantar keratoderma and sensorineural deafness associated with A7445G point mutation in the mitochondrial genome.
Yan AC, Aasi SZ, Alms WJ et al: Aquagenic palmoplantar keratoderma.
Diba VC, Cormack GC, Burrows NP: Botulinum toxin is helpful in aquagenic palmoplantar keratoderma.
Garcon-Michel N, Roguedas-Contios AM, Rault G et al: Frequency of aquagenic palmoplantar keratoderma in cystic fibrosis: a new sign of cystic fibrosis?