palmar-plantar erythrodysesthesia


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palmar-plantar erythrodysesthesia

A toxic effect of chemotherapy, characterized by burning or tingling discomfort in the hands and the soles of the feet occurring after the administration of cancer chemotherapy. Red, violet, and swollen skin may develop on the hands and feet and may shed, crust, or ulcerate. Additional cycles of chemotherapy worsen the effect.
References in periodicals archive ?
The most frequent adverse events (AEs) of grade 3 with greater than 2% incidence in the cabozantinib arm were: diarrhea (16%), palmar-plantar erythrodysesthesia (13%), fatigue (9%), hypertension (8%), decreased weight (5%), decreased appetite (5%), and stomatitis (2%).
The most frequently occurring Grade 3 and Grade 4 adverse events (>5%) regardless of relationship to drug were: fatigue, headache, palmar-plantar erythrodysesthesia, confusional state, alanine aminotransferase increase, convulsion, lymphopenia, hypophosphatemia, lipase increase, diarrhea, aspartate aminotransferase increase, and gait disturbance.
Adverse events of special interest were: hypertension (all incidences, 39%; Grade 3/4, 7%), palmar-plantar erythrodysesthesia (30%; 7%), bleeding events (28%; 9%), proteinuria (26%; 0%), pulmonary embolism (9%; 7%) and craniotomy wound dehiscence (4%; 2%).