Histopathologic Documentation of Treponema pallidum
* Gestational Source, y Age, wk Source of Organism Present case 32 Lung Hardy et al, (4) 1970 30 Aqueous humor, CSF Guarner et al, (7) 1999 26 Small bowel, liver, lung, spleen, lymph node Satin et al, (8) 1992 23 Lung, kidney, pancreas, small and large bowel Benzick, (9) 1999 26 Anterior pituitary Akovbian et al, (10) 1998 Unknown Cutaneous blisters Bennett et al, (11) 1997 Term Skin Knowles and Frost, (12) 1989 Case 1 32 Umbilical cord Case 2 32 Umbilical cord Maternal Source, y Age/Cause of Death Treatment Present case 12.
may also help medical investigators track a syphilis epidemic, St.
Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum
, and herpes simplex virus types 1 and 2 from genital ulcers.
Treponemal tests have equivalent sensitivity but greater specificity for T pallidum
infection compared to non-treponemal tests.
has few surface proteins, complicating the search for a vaccine against syphilis.
infection in olive baboons (Papio anubis) at Lake Manyara National Park in Tanzania (6).
Because T pallidum
is too fragile an organism to be cultured in the clinical setting, diagnostic testing relies on two approaches: direct detection of the organism and indirect evidence of infection.
had developed a mutation that inhibited this ribosomal binding.
was performed by using the Venereal Disease Research Laboratory (VDRL) test, which resulted in a 1:32 dilution, and the T.
Treponemal tests, by contrast, detect antibodies specific to T pallidum
and other pathogenic treponemal species.
When using immunoperoxidase staining for Treponema pallidum
, look for organisms at the perijunctional zone.
Blood bank and plasma testing laboratories will use the assays as primary screening methods in serum or plasma to detect IgG antibodies to Treponema pallidum
and cytomegalovirus (CMV).