Of 203 children (mean age, 11.5 years) with chronic abdominal pain who presented to the gastroenterology clinic at Children's Hospital of Wisconsin, the proportion with abnormally low disaccharidase levels in small-intestinal biopsy samples was 37% for lactase, 21% for sucrase, 25% for glucoamylase (which cleaves glucose from maltose or starch), and 8% for palatinase
A positive test for predicting CD was defined by the following cut-off values for individual DS activity: lactase, [less than or equal to] 15units/g protein; sucrase, [less than or equal to]25units/g protein; maltase, [less than or equal to] 100 units/g protein; and palatinase
, [less than or equal to]5 units/g protein.
Validation results showed the correlation coefficients of the disaccharidases to be 0.98(lactase), 0.93(maltase), 0.95(sucrase), 0.86(Palatinase
), and 0.88(Glucoamylase).