paired helical filaments


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paired helical filaments

Neuropathology Paired structures that are core constituents of the neurofibrillary tangles of Alzheimer's disease and occur in Down syndrome, Hallervorden-Spatz disease, lead encephalopathy, lipofuscinosis, subacute sclerosing panencephalitis, and tuberous sclerosis. See Alzheimer's disease, Neurofibrillary tangles, Senile plaques.
References in periodicals archive ?
Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Seri 99/202 and Ser199/Thr205.
Research indicates hawAD14 significantly decreases levels of Amyloid Beta (A) and tau phosphorylation activity, the main constituents of amyloid plaques and paired helical filaments that make up neurofibrillary tangles in Alzheimer's disease.
Typical AD neuropathological lesions include perikaryal neurofibrillary tangles, which consist of paired helical filaments.