paired helical filaments


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paired helical filaments

Neuropathology Paired structures that are core constituents of the neurofibrillary tangles of Alzheimer's disease and occur in Down syndrome, Hallervorden-Spatz disease, lead encephalopathy, lipofuscinosis, subacute sclerosing panencephalitis, and tuberous sclerosis. See Alzheimer's disease, Neurofibrillary tangles, Senile plaques.
References in periodicals archive ?
Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Seri 99/202 and Ser199/Thr205.
Typical AD neuropathological lesions include perikaryal neurofibrillary tangles, which consist of paired helical filaments.
For example, the Htau mice develop paired helical filaments, neurofibrillary tangles and, eventually, neuronal death.