FURIN

(redirected from paired basic amino acid cleaving enzyme)

FURIN

A gene on chromosome 15q26.1 that encodes a ubiquitous endoprotease, located in the trans-Golgi network membrane of the Golgi apparatus, which is involved in constitutive secretory pathways, cleaving proproteins at the RX(K/R)R consensus motif. Furin releases albumin, complement C3 and vWF from their respective precursors.

Furin has an inhibition peptide, which serves as an intramolecular chaperone, that is autocatalytically removed in the endoplasmic reticulum and remains non-covalently bound to furin as a potent autoinhibitor. After transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
References in periodicals archive ?
Purification and Characterization of Recombinant Human Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4).
Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4) is a eukaryotic endoprotease in the subtilisin-like proprotein convertase (SPC) family.
Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4) is a member of the SPC family that has been implicated in a number of proprotein processing events important in mammalian development, homeostasis, and pathology.