PAH


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PAH

Abbreviation for p-aminohippuric acid.

PAH

,

PAHA

aminohippuric acid.

pulmonary hypertension, primary, type 1

A rare disorder (OMIM:178600) characterised by plexiform lesions of proliferating endothelial cells in pulmonary arterioles, leading to elevated pulmonary arterial pressure, right ventricular failure and death. The disease can occur at any age from infancy onward, but has a mean age of onset at 36 years. Cases secondary to known aetiologies are the more common cause of pulmonary hypertension, and include those associated with appetite-suppressant drugs.

Molecular pathology
May be caused by defects of SMAD9, which encodes a receptor-regulated SMAD, transducing signals from TGF-beta family members.

PAH

1. Polycyclic aromatic hydrocarbon, see there.
2. Pulmonary artery HTN.
References in periodicals archive ?
oBosentan and Ambrisentan have been approved by the FDA for treatment of PAH.
As there are no uniform standard values for the evaluation of PAHs in soil, this study used the standard value for PAH management for agricultural soils in the Netherlands (Annokkee, 1990).
However, further research has found that the prevalence and mortality of PAH are on the rise in the elderly population.
Automobiles, industrial oil combustion, and cooking fuel combustion are the chief source of primary polycyclic aromatic hydrocarbons which gives way to the abundant non-volatile PAH of fine mode and the semi volatile PAH of the coarse mode (Kulkarni and Venkataraman, 2000).
The primary concern in sealcoats are polycyclic aromatic hydrocarbons, or PAHs, which are common products of any type of combustion, and have been shown to be toxic to birds, fish, amphibians, plants and mammals, including humans.
2] The term PAH is reserved specifically for group 1 (Table 1).
The mechanism by which PAH exposure increases the likelihood of ADHD is not fully understood, but the paper lists several possibilities, including the disruption of the endocrine system, DNA damage, oxidative stress, and interference with placental growth factors resulting in decreased exchange of oxygen and nutrients.
PAHs are mostly formed during the incomplete combustion and pyrolysis of fossil fuels or wood, and from the release of petroleum products such as diesel and petrol from fuel combustion in industries and homes.
At the same time, the lowest concentration of PAH in the Buriganga river water samples was related to NAP.
PAH fluxes in the Laja Lake of south central Chile Andes over the last 50 years: evidence from a dated sediment core.
These PAHs form metabolites in the body that can directly destroy the normal structure of DNA and subsequently cause the formation of abnormal proteins and cancerous tumors.
For all validation replicates, measured concentrations of each PAH were generally within 30% of the NIST certified value (maximum error of 55%), and the sum of the PAHs was within 5% of the sum of the NIST certified values.