The investigators reported that the procedures were more technically challenging due to the sclerotic nature of pagetic
A variety of benign and malignant lesions develop in pagetic
Also, when we engineered normal osteoclasts in mice to contain, or express, the measles protein, pagetic
bone lesions formed.
The belief is that the viral infection lies dormant for many years in the person, then an unknown trigger causes activation of the osteoclast, which in turn forms the pagetic
Increase of bone pain at pagetic
sites, possible onset of bone pain at previously asymptomatic sites, and increased risk of fracture in weight-bearing bones.
Quantitative and dynamic analysis of pagetic
and nonpagetic bone tissue.
For example, Gordon et al described the presence of canine distemper virus RNA in pagetic
Fractures in Pagetic
bone are also less stabile, and treatment requires longer periods of immobility.
18]F-fluoride as an imaging agent appears to be of value in measuring regional skeletal metabolism, and therefore may be helpful in determining whether bisphosphonate therapy should be stopped or prolonged depending on the local level of pagetic
activity, he said.
The study population consisted of 10 human volunteers with different disease activities, including 4 healthy individuals, 2 newly diagnosed patients with Paget disease of bone, and 4 Pagetic
patients receiving treatment with bisphosphonate.
Barlow IW, Thomas NP: Reconstruction nailing for subtrochanteric fractures in the Pagetic
X-rays -- Pagetic
bone has a characteristic appearance on x-rays.