pKa


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pKa

The negative decadic logarithm of the ionization constant (Ka) of an acid; equal to the pH value at which equal concentrations of the acid and conjugate base forms of a substance (often a buffer) are present.

pKa

The negative decadic logarithm of the ionization constant (Ka) of an acid; equal to the pH value at which equal concentrations of the acid and conjugate base forms of a substance (often a buffer) are present.
References in periodicals archive ?
pKa Values: The pKa values of the synthesized compounds I-III calculated using potentiometric titration method and predicted using ACD Labs software are all listed in Table-1 and the respective titration curves are showed in Fig.
However, in this study, we found that although mifepristone affected the expression of PKA and PKC as well as a series of downstream key nodes, the levels of LH did not change significantly when FSH secretion decreased.
Stanton, "Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex," American Journal of Physiology.
In Vitro Activation of PPAR-[gamma] Could Inhibit PKA Expression and Neuronal Formation in Spinal Cord-Derived Neural Stem Cells.
PKA signaling pathway has been evidenced to be associated with the pathogenesis of mental disorders, including depression.
In conclusion, our results provided the bases to support the concept that PTX alone could provide useful therapeutic strategies to mitigate RILF and these molecular findings suggest that the downregulatory effect of PTX on PAI-1 may be mediated by PKA despite the absence of an observable effect of PTX on TGF-[beta]/Smad in RILF.
PKA inhibitor H-89 (10 [micro]mol/L) significantly reduced oxLDL-induced MCP-1 expression to 71 [+ or -] 7% ( P = 0.0008), but no further decreasing occurred when H-89 (10 [micro]mol/L) adding with the existing of L-4F (50 [micro]g/ml) ( P = 0.397) [Figure 2].{Figure 2}
Purpose: To evaluate the effect of [alpha]-hederin on PKA and GRK2 mediated phosphorylation of GFP-tagged [[beta].sub.2]AR.
Effects of DDD-Intervening Groups on the Expression of MLCK, cAMP-1, PKC, and PKA in Aorta Tissues of Type 2 Diabetic Rats.
On the contrary, other studies reported that [beta]-adrenergic agonists activate protein kinase A (PKA), which phosphorylates [I.sub.CaL], RyR, PLB, SERCA, and [I.sub.Ks], resulting in delayed afterdepolarization (DADs) [18].
A well characterized intracellular target of cAMP in eukaryotic cells is regulatory subunit of PKA (11,12) and binding of cAMP to regulatory subunits release catalytic subunits to phosphorylate more than 250 target proteins involved in appressorium formation and infection 13.
PKA president Jay Ortiz said this year's tour will consist of four legs and feature new destination stops in the PKA's continuing effort to promote the sport and showcase the Philippines as one of Asia's top kitesurfing destinations.