CDKN1C

(redirected from p57Kip2)

CDKN1C

A gene on chromosome 11p15.5 that encodes a strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation.

Molecular pathology
CDKN1C mutation is implicated in sporadic cancers and Beckwith-Wiedemann syndrome, suggesting a role in tumour suppression.
References in periodicals archive ?
Differential expression of p57kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease.
Objective of the present study was the diffe-rentiation and comparison between complete and partial hydatidiform mole on the basis of p57KIP2 ex-pression.
2006) CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene.
Re-evaluation of the histological criteria for complete hydatidiform mole: Comparison with the immunohistochemical diagnosis using p57KIP2 and CD34.
Expression of cell cycle regulator p57kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: an immunohistochemical study.
6) Caracteristica Mola completa Mola parcial Edema vellosidades Pronunciado y global Leve y focal Hiperplasia Compromiso Compromiso focal trofoblastica circunferencial Atipia trofoblastica Moderado a marcado Leve Inmunohistoquimica Ausencia de p57KIP2 y Presencia P57kip2 Y PHLDA2 phlda2 Cariotipo Generalmente 46XX Generalmente triploide, uniparental biparental Elementos Ausentes Presentes embrionarios/fetales Niveles de hCG Comunmente marcada Poco comun marcada elevacion elevacion Tamano uterino A menudo mayor para la A menudo consistente edad gestacional con la edad gestacional Quistes de la teca Comun Infrecuente luteinica Neoplasia 18-28% 2-4% trofoblastica gestacional post molar
P57kip2 expression can be used in association with the histological findings for a definitive diagnosis.
6) Caracteristica Mola completa Mola parcial Edema vellosidades Pronunciado y Leve y focal global Hiperplasia Compromiso Compromiso trofoblastica circunferencial focal Atipia trofoblastica Moderado a Leve marcado Inmunohistoquimica Ausencia de Presencia p57KIP2 y P57kip2Y PHLDA2 phlda2 Cariotipo Generalmente Generalmente 46XX triploide, uniparental biparental Elementos Ausentes Presentes embrionarios/fetales Niveles de hCG Comunmente Poco comun marcada marcada elevacion elevacion Tamano uterino A menudo mayor A menudo para la edad consistente gestacional con la edad gestacional Quistes de la teca Comun Infrecuente luteinica Neoplasia 18-28% 2-4% trofoblastica gestacional post molar
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
Mutantpolycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
5 syndrome hemangioendothelioma Li-Fraumeni syndrome Hepatoblastoma, undifferentiated 17p13 sarcoma Trisomy 18 Hepatoblastoma 18 Glycogen storage Hepatocellular adenoma or 17 disease types Ia, carcinoma, hepatoblastoma III, IV Disease Gene Familial adenomatous APC polyposis Beckwith-Wiedemann p57KIP2, others syndrome Li-Fraumeni syndrome TP53 Trisomy 18 .
Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.