CDKN1C

(redirected from p57Kip2)

CDKN1C

A gene on chromosome 11p15.5 that encodes a strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation.

Molecular pathology
CDKN1C mutation is implicated in sporadic cancers and Beckwith-Wiedemann syndrome, suggesting a role in tumour suppression.
References in periodicals archive ?
P57KIP2 immunostaining and molecular cytogenetics: combined approach aids in diagnosis of morphologically challenging cases with molar phenotype and in detecting androgenetic cell lines in mosaic/chimeric conceptions.
Expression of cell cycle regulator p57kip2, cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: an immunohistochemical study.
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
Mutantpolycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
5 syndrome hemangioendothelioma Li-Fraumeni syndrome Hepatoblastoma, undifferentiated 17p13 sarcoma Trisomy 18 Hepatoblastoma 18 Glycogen storage Hepatocellular adenoma or 17 disease types Ia, carcinoma, hepatoblastoma III, IV Disease Gene Familial adenomatous APC polyposis Beckwith-Wiedemann p57KIP2, others syndrome Li-Fraumeni syndrome TP53 Trisomy 18 .
Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.
An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.
Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome.
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2.