LCK

(redirected from p56lck)

LCK

A gene on chromosome 1p34.3 that encodes a member of the Src family of non-receptor tyrosine kinases that is involved in the selection and maturation of developing T cells. LCK localises to the plasma membrane and pericentrosomal vesicles and binds to cell surface receptors, including CD4 and CD8, and other signalling molecules.
 
Molecular pathology
LCK translocation t(1;7)(p34;q34) with TCRB may be found in leukaemia.
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References in periodicals archive ?
Defective protein tyrosine phosphorylation and altered levels of p59fyn and p56lck in CD4T cells from HIV-1 infected patients.
Yodoi, "Redox regulation of a src family protein tyrosine kinase p56lck in T cells," Oncogene, vol.