MAPK12

(redirected from p38gamma)

MAPK12

A gene on chromosome 22q13.33 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK12 is activated by environmental stress and pro-inflammatory cytokines, in turn phosphorylating downstream
targets. It plays a role in myoblast differentiation and downregulates cyclin D1 in response to hypoxia.
References in periodicals archive ?
The Gothenburg scientists then proceeded to investigate the effect of imidazole propionate on sugar metabolism and found that the molecule affected a signalling pathway previously linked to metabolic-related diseases by directly activating a specific protein, p38gamma.
Cuenda, "New insights into the p38gamma and p38delta MAPK pathways," Journal of Signal Transduction, vol.
Mambol et al., "p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation," Proceedings of the National Academy of Sciences of the United States of America, vol.
MAPK11 (also referred to as p38BETA) is one of the four members of the p38MAPK family (p38alpha, p38beta, p38gamma, and p38delta).
(2009) p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.