MAPK12

(redirected from p38gamma)

MAPK12

A gene on chromosome 22q13.33 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK12 is activated by environmental stress and pro-inflammatory cytokines, in turn phosphorylating downstream
targets. It plays a role in myoblast differentiation and downregulates cyclin D1 in response to hypoxia.
References in periodicals archive ?
2009) p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.
Selective activation of p38alpha and p38gamma by hypoxia: role in regulation of cyclin D1 by hypoxia in PC12 cells.