MAPK13

(redirected from p38delta)

MAPK13

A gene on chromosome 6p21.31 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK13 is phosphorylated and activated by MAP kinases—especially MKK3 and MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress, and in turn phosphorylate downstream targets.
References in periodicals archive ?
Efimova, "p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis," Cell Cycle, vol.
Eckert, "A regulatory role for p38delta MAPK in keratinocyte differentiation: evidence for p38delta-ERK1/2 complex formation," The Journal of Biological Chemistry, vol.
Toriseva et al., "p38delta mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes," Archives of Dermatological Research, vol.
Collins et al., "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis," Cell, vol.
Gribben et al., "p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice," Cancer Research, vol.
Barry, "p38delta MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma," Anti-Cancer Drugs, 2014.
Mambol et al., "p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation," Proceedings of the National Academy of Sciences of the United States of America, vol.
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem.
Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/ p38delta at Thr50 promotes microtubule assembly.
MAPK11 (also referred to as p38BETA) is one of the four members of the p38MAPK family (p38alpha, p38beta, p38gamma, and p38delta).