MAPK14

(redirected from p38ALPHA)

MAPK14

A gene on chromosome 6p21.3-p21.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK14 is phosphorylated and activated by MAP kinases or autophosphorylated by interaction with MAP3K7IP1/TAB1 protein.

MAPK14 substrates
Transcription regulator ATF2, cell cycle regulator CDC25B and tumour suppressor p53, suggesting that MAPK14 has a role in stress-related transcription and cell cycle regulation, as well as in
genotoxic stress response.
References in periodicals archive ?
Comparative expression profiling identifies differential roles for Myogenin and p38alpha MAPK signaling in myogenesis.
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.
Wu et al., "p38alpha MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine," Journal of Experimental & Clinical Cancer Research, vol.
Tooze, "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP," The EMBO journal, vol.
Gram, F di Padova et al., "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha," Science, vol.
MAPK11 (also referred to as p38BETA) is one of the four members of the p38MAPK family (p38alpha, p38beta, p38gamma, and p38delta).
The target is a stress-related protein kinase, p38alpha MAPK.
Kaneko et al., "The p38alpha MAPK regulates microglial responsiveness to diffuse traumatic brain injury," Journal of Neuroscience, vol.
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
Shen et al., "p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and--9 expression and cell migration in human lovo colon cancer cells," Journal of Cellular Physiology, vol.
A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss.