MAPK14

(redirected from p38ALPHA)

MAPK14

A gene on chromosome 6p21.3-p21.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK14 is phosphorylated and activated by MAP kinases or autophosphorylated by interaction with MAP3K7IP1/TAB1 protein.

MAPK14 substrates
Transcription regulator ATF2, cell cycle regulator CDC25B and tumour suppressor p53, suggesting that MAPK14 has a role in stress-related transcription and cell cycle regulation, as well as in
genotoxic stress response.
References in periodicals archive ?
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.
Bachstetter AD et al (2011) Microglial p38alpha MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Abeta).
The target is a stress-related protein kinase, p38alpha MAPK.
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
Selective activation of p38alpha and p38gamma by hypoxia: role in regulation of cyclin D1 by hypoxia in PC12 cells.
A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss.
Amphora's most advanced compounds are preclinical candidates in the areas of oncology and inflammation which are exquisitely specific inhibitors for AKT1 and p38alpha respectively.
Two of Amphora's most advanced compounds are preclinical candidates in the areas of oncology and inflammation which are exquisitely specific inhibitors for AKT1 and p38alpha respectively.
Iwanowicz will head the medicinal chemistry teams working on all of Triad's lead discovery and lead optimization programs including Triad's anti- inflammatory program against the protein kinase, p38alpha and Triad's antibacterial program against the bacterial enzyme, EACPR.