MAPK14

(redirected from p38 mitogen activated protein kinase)

MAPK14

A gene on chromosome 6p21.3-p21.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK14 is phosphorylated and activated by MAP kinases or autophosphorylated by interaction with MAP3K7IP1/TAB1 protein.

MAPK14 substrates
Transcription regulator ATF2, cell cycle regulator CDC25B and tumour suppressor p53, suggesting that MAPK14 has a role in stress-related transcription and cell cycle regulation, as well as in
genotoxic stress response.
References in periodicals archive ?
More surprisingly, without influencing phosphorylation of Akt, mTOR-independent autophagy inducer trehalose may ameliorate insulin resistance-induced myocardial contractile defect and apoptosis, by means of autophagy associated with dephosphorylation of p38 mitogen activated protein kinase (p38 MAPK) and Forkhead box O 1 (Foxo1) [45].
Recent study reported that eotaxin could activate extracellular signal regulated kinase 2 (ERK2) and p38 mitogen activated protein kinase (MAPK) to stimulate the migration of eosinphils to epithelial cells, then activate, produce and release several inflammatory mediators to induce airway inflammation.13 In addition, the elevated eotaxin levels were also observed in allergicrhinitis.14 All these above suggested that IL-17 and eotaxin play a critical role in asthma and allergic rhinitis.