MAPK14

(redirected from p38 MAP kinase)

MAPK14

A gene on chromosome 6p21.3-p21.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK14 is phosphorylated and activated by MAP kinases or autophosphorylated by interaction with MAP3K7IP1/TAB1 protein.

MAPK14 substrates
Transcription regulator ATF2, cell cycle regulator CDC25B and tumour suppressor p53, suggesting that MAPK14 has a role in stress-related transcription and cell cycle regulation, as well as in
genotoxic stress response.
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References in periodicals archive ?
Signaling pathway for TNF-alpha-induced MMP-9 expression: Mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells.
Neflamapimod is a brain-penetrant oral small molecule that inhibits the intra-cellular enzyme p38 MAP kinase alpha.
Collins, "[beta]-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase," Journal of Biological Chemistry, vol.
(6,16,17) In this study, we observed increased production of inflammatory cytokines, which suggested the activation of p38 MAP kinase by persistent leishmanial proteins in renal tissues that further augment of TNF-[alpha], IFN-[gamma], and IL-12 production.
Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury.
Surh, "Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: P38 MAP kinase and JNK as potential targets," Archives of Biochemistry and Biophysics, vol.
Western blotting for phosphorylated forms of p38 MAP kinase (p-p38 Map kinase) was performed as described previously [15].
Han, "Activation and signaling of the P38 MAP kinase pathway," Cell Research, vol.
UK-based Mereo BioPharma Group has reported positive results for its Phase one drug interaction study with acumapimod, the active compound in its p38 MAP kinase inhibitor, BCT-197, it was reported on Friday.
Abbreviations: ZY, zymosan; CG, carrageenan; fMLP, N-formyl-methionyl-leucylphenylalanine; LPS, lipopolysaccharide; IL, interleukin; TNF-[alpha], tumor necrosis factor [alpha]; NF-kB, nuclear factor-kB; MAPKs, mitogen-activated protein kinase; p38, p38 MAP kinase; ERK1/2, extracellular signal-regulated protein kinase; JNK, c-Jun N-terminal protein kinase; DEXA, dexamethasone; [PGE.sub.2], prostaglandin [E.sub.2].
(2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.