Signaling pathway for TNF-alpha-induced MMP-9 expression: Mediation through p38 MAP kinase
, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells.
Neflamapimod is a brain-penetrant oral small molecule that inhibits the intra-cellular enzyme p38 MAP kinase
Collins, "[beta]-Adrenergic activation of p38 MAP kinase
in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
," Journal of Biological Chemistry, vol.
(6,16,17) In this study, we observed increased production of inflammatory cytokines, which suggested the activation of p38 MAP kinase
by persistent leishmanial proteins in renal tissues that further augment of TNF-[alpha], IFN-[gamma], and IL-12 production.
Activation of p38 MAP kinase
in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury.
Surh, "Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: P38 MAP kinase
and JNK as potential targets," Archives of Biochemistry and Biophysics, vol.
Western blotting for phosphorylated forms of p38 MAP kinase
(p-p38 Map kinase) was performed as described previously .
Han, "Activation and signaling of the P38 MAP kinase
pathway," Cell Research, vol.
UK-based Mereo BioPharma Group has reported positive results for its Phase one drug interaction study with acumapimod, the active compound in its p38 MAP kinase
inhibitor, BCT-197, it was reported on Friday.
Abbreviations: ZY, zymosan; CG, carrageenan; fMLP, N-formyl-methionyl-leucylphenylalanine; LPS, lipopolysaccharide; IL, interleukin; TNF-[alpha], tumor necrosis factor [alpha]; NF-kB, nuclear factor-kB; MAPKs, mitogen-activated protein kinase; p38, p38 MAP kinase
; ERK1/2, extracellular signal-regulated protein kinase; JNK, c-Jun N-terminal protein kinase; DEXA, dexamethasone; [PGE.sub.2], prostaglandin [E.sub.2].
(2002) A conserved p38 MAP kinase
pathway in Caenorhabditis elegans innate immunity.