IL27

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IL27

A gene on chromosome 16p11 that encodes interleukin-27, a pro- and anti-inflammatory cytokine that regulates T-helper cell development, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, and which has diverse effects on innate immune cells. Its target cells include CD4 T-helper cells, which can differentiate in types 1 and 2 effector cells (TH1 and TH2), and IL17-producing helper T-cells (TH17); it drives rapid clonal expansion of naïve CD4 T-cells. It strongly synergises with IL12 to trigger interferon-gamma production by naïve CD4 T-cells and binds to the cytokine receptor WSX-1/TCCR, which appears to be required for IL27-mediated signal transduction. IL27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It also has antitumour and antiangiogenic activity, with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL27 is also a less preferred gene symbol for what is now designated as IL17D, see there.
References in periodicals archive ?
Pangarungan said about 30 OFWs approached him for picture-taking and admitted having 'sneak(ed) in' with at least 300 others for a fee of 2,000 to 2,500 Saudi Riyals (P28,000 to P35,000).
Consolidated gross gaming revenues (GGR) for the first half of the year grew 10 percent to P28.62 billion, from P26.13 billion last year.
P28 Million giant clams seized in Negros Occidental !-- -- Gilbert Bayoran (The Philippine Star) - August 6, 2019 - 12:00am BACOLOD CITY, Philippines Around seven tons of giant clams, locally known as taklobo or manlot, were seized in Escalante City, Negros Occidental on Friday.
The firm said loans and receivables amounted to P28.7 billion, largely due to the sale of a portion of its lower-yielding portfolio earlier this year to mitigate the impact of compressed margins.
Governor Wycliffe Oparanya in Kakamega has hired 16 MCAs who lost elections as community administrators (see P28).
The donations include 960 pieces soap bars worth P26,880; 1,920 pieces of toothbrush worth P28,800; 400 pieces dish washing liquid worth P17,200; and 960 laundry powder worth P4,800.
The collaboration is in connection with P28 billion deal of the Philippine government to South Korea secured last June 6.
With increasing age and the development of retinal degeneration, most spindle-like Lopsin-positive fluorescence changed into shorter punctate fluorescence in the P28 rd11 retina, and punctate fluorescence was significantly reduced in the P42 rd11 retina, especially in the ventral/temporal and ventral/nasal quadrants (Figure 2).
EToday it has been revealed (p28) that if you board an Arriva Train Wales carriage it could be 24 years old.
I WAS just Looking through the February issue of Kai Tiaki Nursing New Zealand and came upon the viewpoint, "Nursing in a bicultural society" (p28).
The brand new P28 High Protein Bagels are 100% natural, 100% whole wheat, and include a generous 28 grams of protein.
ACCIDENTAL DISCOVERY OF A POTENTIAL ANTICANCER DRUG: THE STORY OF AZURIN AND P28