IL27

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IL27

A gene on chromosome 16p11 that encodes interleukin-27, a pro- and anti-inflammatory cytokine that regulates T-helper cell development, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, and which has diverse effects on innate immune cells. Its target cells include CD4 T-helper cells, which can differentiate in types 1 and 2 effector cells (TH1 and TH2), and IL17-producing helper T-cells (TH17); it drives rapid clonal expansion of naïve CD4 T-cells. It strongly synergises with IL12 to trigger interferon-gamma production by naïve CD4 T-cells and binds to the cytokine receptor WSX-1/TCCR, which appears to be required for IL27-mediated signal transduction. IL27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It also has antitumour and antiangiogenic activity, with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL27 is also a less preferred gene symbol for what is now designated as IL17D, see there.
References in periodicals archive ?
The country's leading lender BDO Unibank chalked up a record high net profit of P28.
In a disclosure to the Philippine Stock Exchange on Monday, BDO announced a net income of P28.
2 billion, higher by 13 per cent, with fee-based income accounting for P28.
Tenders are invited for Repairing Of 07 Nos Vcs Touch Screen For Yard 3017N P28
The brand new P28 High Protein Bagels are 100% natural, 100% whole wheat, and include a generous 28 grams of protein.
ACCIDENTAL DISCOVERY OF A POTENTIAL ANTICANCER DRUG: THE STORY OF AZURIN AND P28
Para o periodo de 14 a 28 dias, os animais recebendo zinco suplementar tiveram maior P28 e GDP (P<0,05) e observou-se interacao significativa (P<0,05) entre proteina lactea e zinco suplementar para P28 e GDP.
Letters editor's note: Mr Witts would want to see our story on p28 of this issue, "Zimbabwe, Our economy is under siege, says Mugabe").
p2lWafl/Cipl is an inhibitor of cyclin-dependent kinases involved in regulation of cell division and was the founding member of a family of functionally related kinase inhibitors (cycin-dependent kinase inhibitors; CKIs), now known to include p27, p28, p57, and DACAPO.
16 mg/kg) Phase I trial to evaluate the safety, tolerability, immunogenicity, pharmacokinetics and pharmacodynamics (PK/PD) of p28 as a single agent.
Why ask for a kickback when the contractor is even losing in the P28 million?
Tenders are invited for Modification Job For Satcom B For Aswc Grse Yard No 3019 20 P28