A cyclin-dependent kinase inhibitor which binds to cyclinE/cdk2, blocking the G1/S transition step required for cell cycle progression. It is upregulated by cell stress, resulting in inhibition of cell cycling and apoptosis, and may have a role in tumour supression, cell migration and mitosis; low p27 expression has been reported in breast, colourectal, gastric, lung and brain cancer. Decreased p27 expression is associated with a poorer prognosis. p27 is downregulated through degradation by ubiquitin-dependent proteolysis
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MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1.
Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53p21 WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma: independent prognostic value of p27Kip1.
By inhibiting p27Kip1, a cyclin dependent kinase inhibitor or CKI, supporting cell and auditory hair cell regeneration is stimulated in adult mice and Guinea pigs that were previously exposed to intense noise or ototoxic drugs.
A relation of survivin and hTERT was suggested by Zhang et al (22) in gastric carcinoma cells; they detected down-regulation of survivin expression by Western blot and inhibition of telomerase activity by telomerase repeat amplification protocol by upregulation of p27kip1.
miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and de crease in retinoblastoma protein (pRb) phosphorylation.
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.
Similarly, E7 can antagonize the ability of p27KIP1 to block cyclin E-associated kinase in vitro (21).
p21WAF1 (p21) and p27KIP1 (p27) are both universal inhibitors of cyclin-dependent kinases and can therefore influence cell cycle or tumor progression.
Prognostic significance of expression patterns of c-erbB-2, p53, p16INK4A, p27KIP1, cyclin D1 and epidermal growth factor receptor in oesophageal adenocarcinoma: a tissue microarray study.
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.