CYBA

(redirected from p22phox)

CYBA

A gene on chromosome 16q24.3 that encodes the cytochrome b alpha chain, which is a primary component of the microbicidal oxidase system of phagocytes.
References in periodicals archive ?
CGD is caused by the mutations in four different genes involved in the NADPH oxidase system (i.e., gp91phox, p22phox, p47phox, and p67phox).
(a) The protein expression of hepatic [p47.sup.phox]; (b) the protein expression of hepatic p22phox. (1) p < 0.01 versus C/C group; (2) p < 0.01 versus C/LHF group; (3) p < 0.01 versus C/HHF group; (4) p < 0.01 versus LHF/LHF group.
In addition to functions in glucose and lipid metabolism and cell proliferation and differentiation, PPAR-[gamma] can also alleviate the acute and chronic inflammatory response after nerve injury and ameliorate neuronal apoptosis and ischemic brain injury by suppressing NF-[kappa]-driven p22phox transcription [18].
showed a clear association between diabetic polyneuropathy and the C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox allele of CYBA gene [52].
Mizotani et al., "Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of MRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells," Life Sciences, vol.
Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression.
Kanegasaki, "Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22phox deficiency, " Human Genetics, vol.
Marques et al., "Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus," BMC Medical Genetics, vol.
After microbial infection or ligation of TLR2, Rubicon interacts with the p22phox subunit of the NADPH oxidase complex, accelerating its phagosomal trafficking to induce a burst of ROS and inflammatory cytokines.
The classical NADPH oxidase found in neutrophils is composed of five subunits: p47phox, p67phox, p40phox, p22phox, and gp91phox (catalytic subunit, also known as NADPH oxidase isoform 2 (NOX2)) [46, 47].
It is reported that SIRT1 activation can induce PGC-1[alpha] activity by facilitating SIRT1-mediated deacetylation and subsequently reduce peroxisome proliferator activated receptor-[alpha] (PPAR-[alpha]) activation, which results in downregulation of the NADPH oxidase subunits p22phox and NOX4.
Administration of rosmarinic acid reduces cardiopathology and blood pressure through inhibition of p22phox NADPH oxidase in fructose-fed hypertensive rats.