CYBA

(redirected from p22-PHOX)

CYBA

A gene on chromosome 16q24.3 that encodes the cytochrome b alpha chain, which is a primary component of the microbicidal oxidase system of phagocytes.
References in periodicals archive ?
Identification of Nef-HIV-1 domains involved in p22-phox interaction and superoxide production.
NOX2 NADPH oxidase is composed by functional transmembrane heterodimers, gp91-phox and p22-phox (also known as cytochrome b558), and four regulatory cytosolic subunits p40-phox, p47-phox, p67-phox, and Rac2 (8).
Several pathways could explain ROS modulation: 1) Nef can induce superoxide production by activating PAK (p21-activated kinase) in a Cdc42/Rac dependent manner (10); 2) Nef interacts with Hck (hemopoietic cell kinase) and can induce phosphorylation and membrane translocation of p47-phox (9); and 3) Nef interacts with p22-phox and could directly affect NOX2 NADPH-activity (17).
4) at room temperature for 1 hour and next incubated with rabbit-anti-mouse primary antibodies overnight at 4[degrees]C: Ang II type 1 receptor (AT-1R, 1:1000), NADPH oxidase 1 (NOX-1, 1: 1000), NOX-4 (1: 1000), p22-phox (1:1000), p47-phox (1:1000), extracellular regulated protein kinases 1/2 (ERK1/2, 1:1000), p-ERK1/2 (1:1000), p38 MAPK (1: 1000), p-p38 MAPK (1: 500), TGF-[beta]1 (1: 100), [alpha]-SMA (1:100), and GAPDH (1:1000).
Changes in Expression of AT-1R, TGF-[beta]1, p22-phox, and p47-phox in Kidney Tissue in Mice after Different Treatment.
Compared with the normal group, p22-phox and p47-phox (both were NADPH oxidase subunits) were upregulated in nontreated db/db mice, while EGCG treatment significantly reduced the protein expression of p22-phox and p47-phox in db/db mice (Figures 3(a), 3(b), and 3(c), P < 0.
The membrane bound cytochrome b558 composed of large gp91-phox and small p22-phox subunits, and cytosolic proteins p40-, p47and p67-phox are important components of superoxide (O(2)(-))-generating system in phagocytes and B lymphocytes.
Transfected K562 cells that permanently express gp91-phox, p47-phox, and p67-phox and have endogenous p22-phox were a kind gift from Dr.
K562 cells containing no endogenous peroxidase and transfected to express gp91-phox, p47-phox, and p67-phox [and having endogenous p22-phox (31)] provided a model to investigate the peroxidase dependency of PMA-induced DHR oxidation by [H.
The most common autosomal recessive form results from a defect in p47-phox, whereas a rare form occurs because a deficiency of p67-phox or p22-phox [2].
Mutations affecting any of the four subunits gp91-phox, p22-phox, p47-phox, or p67-phox either render phagocytes from CGD patients incapable of superoxide generation after stimulation or strongly decrease its production (6).
The p22-phox gene is located on chromosome 16g24, and therefore a mosaic of nonpathologic and defective cells is not likely because of a mutation in this gene.