HRAS

(redirected from p21ras)

HRAS

A gene on chromosome 11p15.5 belonging to the Ras oncogene family, the protein products of which bind GTP and GDP, have intrinsic GTPase activity, and play key roles in signal transduction. HRAS cycles between de- and re-palmitoylation, a reaction that regulates its rapid exchange between the plasma membrane and the Golgi apparatus.

Molecular pathology
Defects in HRAS are associated with an increased risk of bladder cancer, Hürthle cell carcinoma of thyroid, and oral squamous cell carcinoma. HRAS mutations cause faciocutaneoskeletal syndrome and congenital myopathy with excess of muscle spindles—a variant of Costello syndrome.
References in periodicals archive ?
The ras proteins, or p21ras, belong to the small guanosine triphosphatase superfamily, of which KRAS, HRAS, and NRAS are the 3 best known among various members.
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras.
1995) Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions.
Beta-hexosaminidase-induced activation of p44/42 mitogen-activated protein kinase is dependent on p21Ras and protein kinase C and mediates bovine airway smooth-muscle proliferation.
Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras.
Scientists demonstrated that virgin olive oil is associated with higher incidences of benign breast tumours and at the same time with a decrease in the activity of the p21Ras oncogene, which spurs uncontrolled cell proliferation and stimulates the growth of tumours.
The mitogenic action is mediated through binding of phosphorylated IRS1/2 or Shc with Grb-2/SOS complex leading to p21Ras and Raf-1 activation of mitogen-activated protein kinase pathway (MAPK) (21).
The authors have shown that the activity of one protein called p21Ras is increased very early in the midbrain of mice with Parkinson's pathology.
Mutational an non-mutational activation of p21ras in rat colonic azoxymethane-induced tumors: efeccts on mitogen-activated protein kinase, cycloxygenase-2, and cyclin D1.
Nitric oxide activates p21ras and leads to the inhibition of endothelial NO synthase by protein nitration.
and Kalbitzer HR: Conformational transitions in p21ras and in its