HRAS

(redirected from p21ras)

HRAS

A gene on chromosome 11p15.5 belonging to the Ras oncogene family, the protein products of which bind GTP and GDP, have intrinsic GTPase activity, and play key roles in signal transduction. HRAS cycles between de- and re-palmitoylation, a reaction that regulates its rapid exchange between the plasma membrane and the Golgi apparatus.

Molecular pathology
Defects in HRAS are associated with an increased risk of bladder cancer, Hürthle cell carcinoma of thyroid, and oral squamous cell carcinoma. HRAS mutations cause faciocutaneoskeletal syndrome and congenital myopathy with excess of muscle spindles—a variant of Costello syndrome.
References in periodicals archive ?
Otros mecanismos mediante los cuales los acidos grasos omega-3 pueden inhibir la progresion de la carcinogenesis, incluyen regulacion en la transduccion de senales de regulacion de la expresion genica, por ejemplo, disminucion de la activacion del factor de transcripcion nuclear NF-[kappa]B de oncogenes ras, supresion de la expresion de p21ras y COX-2 (ciclooxigenasa-2).
Gallo-Payet, "Signals from the AT2 (angiotensin type 2) receptor of angiotensin II inhibit p21ras and activate MAPK (mitogen-activated protein kinase) to induce morphological neuronal differentiation in NG108-15 cells," Molecular Endocrinology, vol.
Delovitch, "Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation," Journal of Experimental Medicine, vol.
Fletcher et al., "Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis," Cell, vol.
Malik, "Beta-hexosaminidase-induced activation of p44/42 mitogen-activated protein kinase is dependent on p21Ras and protein kinase C and mediates bovine airway smooth-muscle proliferation," American Journal of Respiratory Cell and Molecular Biology, vol.
Nyce, "Inhibition of Protein Isoprenylation and p21ras Membrane Association by Dehydroepiandrosterone in Human Colonie Adenocarcinoma Cells in Vitro," Cancer Research, vol.
Novogrodsky, "p21ras as a common signaling target of reactive free radicals and cellular redox stress," Journal of Biological Chemistry, vol.
RAGE occupation causes oxidative stress and activation of NF-[kappa]B via the p21ras and the mitogen-activated protein kinase signaling pathway.
The ras proteins, or p21ras, belong to the small guanosine triphosphatase superfamily, of which KRAS, HRAS, and NRAS are the 3 best known among various members.
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Mol Cell Biol 1993 Jan;13(1):155-162.
(1995) Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions.
Leitner et al., "Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals," Diabetologia, vol.