p21


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CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.

p21

Also known as p53 protein, an anticancer protein of the class of cyclin-dependent kinase inhibitors. Cyclin-dependent kinases are enzymes that have been described by Elizabeth Finkel as ‘the engines that drive the cell-cycle past its various control checkpoints.’ Inhibition of these enzymes provides a way of controlling rapidly-reproducing cells such as cancer cells. High levels of p21 are found in ageing cells. p21 protein is dysfunctional in most human cancers.
References in periodicals archive ?
The p21 (tumor suppressor gene) is also known as cyclin dependent kinase inhibitor 1A, located on canine chromosome 12.These cyclin dependent kinase inhibitors(CDKIs), group of inhibitory proteins that control the cyclin dependent kinase activity and cell cycle progression in response to the intracellular and extracellular signals (Vidal and Koff 2000).
The BSP registered FX rate gains - which are realized gains from FX rate fluctuations - of P9 billion end-June this year versus P21.51 billion same period in 2018.
Interest expense surged by 65 percent to P21.49 billion from P13.02 billion.
Nick Santos, head of the VIB food hygiene and regulatory division, said 167 kilograms of chicken meat worth some P21,000 was seized at the Pampanga Market around 6 a.m.
These are the P21 million road connecting villages of Macrohon and Malitbog towns, and P21 million road upgrading in four villages in Hinunangan town, she added.
From June 12 to 14, the dining complex which offers an authentic seafood market experience, will have a food flash sale where a kilo of local crabs will be sold for only P21!
The following four land uses were evaluated: natural grassland (NG), five-year-old (P5), 16-year-old (P16) and 21-year-old (P21) pine (Pinus taeda) plantations.
The effects of Grail on the expression of p53 and p21 were analyzed by real-time polymerase chain reaction and Western blot for KB cells (KB/vector, KB/Grail and KB/shGrail).
Through November 10, P21 Gallery in London is running a " Sudan / South Sudan Literature Week ":
Mr Raja said the donations were worth a little over P21 000.
When the optimal concentration of the CSE solution (0.05 ml) was added to the cells for durations of 0, 3, 6, and 12 hours (Supplementary Figure 1), the total extracted protein was used to detect P16 and P21 expression by western blotting to determine the best reaction time.
Finally, karyotype of the mother was designated as 46, XX, t (2;7)(p13?; q32?), ins (7;2)(q22?;q?q?), inv (7)(p12p21).ish t(2;7)(p13?; q32?), (wcp7+;wcp2+),ins(7;2)(22q;q?q?) (wcp2+), inv (7)(p21)(TWIST1)(p11)(ELN).