p21


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CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.

p21

Also known as p53 protein, an anticancer protein of the class of cyclin-dependent kinase inhibitors. Cyclin-dependent kinases are enzymes that have been described by Elizabeth Finkel as ‘the engines that drive the cell-cycle past its various control checkpoints.’ Inhibition of these enzymes provides a way of controlling rapidly-reproducing cells such as cancer cells. High levels of p21 are found in ageing cells. p21 protein is dysfunctional in most human cancers.
References in periodicals archive ?
The capex for regulatory year (RY) 2019 is in the order of about P21 billion,' he said.
Meralco) has applied for a capital expenditure (capex) of about P21 billion for 2019.
CABUCGAYAN, Biliran - This town received over P21 million worth of assistance from the Department of Agriculture Regional Field Office (DA-RFO 8), based in Tacloban City.
Call center agents and other employees with a monthly income of P21,000 will be exempted from paying the personal income tax (PIT), generating savings of over P20,000 annually, under the first package of the comprehensive tax reform plan (CTRP) as crafted and filed by the head of the House ways and means committee in close coordination with the Department of Finance (DOF).
London's P21 Gallery is hosting an exhibition of Sudanese art, to be accompanied by lectures, film, and theatre.
Wild-type P53, a nuclear phosphoprotein, has been shown to be a sequence specific transcription factor which induces the expression of P21, WAF1/C1 P1/Sdi-1, leading to a G1 arrest checkpoint to step up repair before DNA replication and contributes to normal cell proliferation; unless DNA replication is successful, the cells will be induced to undergo apoptosis.
Next row (WS): P21 (22, 23, 26, 28), pm, k38 (40, 42, 44, 48), pm, p21 (22, 23, 26, 28).
The majority of work has been secured under the P21 and P21+ Healthcare national frameworks and with more opportunities in the pipeline.
Design_atelier_, part of Kalimat Magazine, is organising an exhibition of local talented artists to be shown in London at the P21 Gallery.
RichardJMoir Andrew Haines 2013: P21 W3 D3 L15 F16 A37 Pts 12 GD -21 #embarrassed @BoroinBucks Razmoo ALL Boro players that have been part of this season's shambles - I hope you have the bottle to apologise to the fans who pay your wages.
In the past 10 years, starting with the 2002 series against Sri Lanka, their record is P21 W15 D5 L1.
P21 GmbH, a subsidiary of Heliocentris Energy Solutions, has been awarded another order from the du, to implement its 'Genset Efficiency' solution in 57 additional mobile network base station sites.