P19-INK4D | definition of p19-INK4D by Medical dictionary
CDKN2D (redirected from p19-INK4D)
CDKN2D A gene on chromosome 19p13 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 and CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2D inhibits neuronal proliferation, as well as spermatogenesis.
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References in periodicals archive
Overexpression of cyclin-dependent kinase inhibitor 1 (WAF1) from the kinase inhibitor protein group and PAK-[gamma] (p21- activated kinase [gamma]), combined with overexpression of CDKN2D (p19-INK4D
) and cell division protein kinase 3 (CDK3), denote a major derangement in the regulation of cell-cycle progression.