CDKN2B

(redirected from p15INK4b)

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
References in periodicals archive ?
Location of primers PCR product according to transcription length (bp) start point APC U02509 -17 147 / -17 050 108 -17 153 / -17 046 97 DAPK NM_004938 -332 / -229 103 -332 / -234 98 HMLH1 AB017806 -526 / -661 125 -531 / -655 124 p15INK4B NM_004936 -318 /-188 130 -312 / -187 125 p16INK4A NM_000077 -80 / +46 126 -80 / +44 124 P73 AB031234 -1585 / -1505 80 -1588 / - 1510 78 PCR: Polymerase chain reaction, APC: Adenomatous polyposis cair, DAPK1: Death-associated protein kinase Table 3.
Beach, "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest," Nature, vol.
Zeisel, "Maternal choline availability alters the localization of p15Ink4B and p27Kip1 cyclin-dependent kinase inhibitors in the developing fetal rat brain hippocampus," Developmental Neuroscience, vol.
Hokland, "Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients," European Journal of Haematology, vol.
Wolff, "Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML," Blood, vol.
The main components of RB pathway involves five family proteins; retinoblastoma tumor suppressor RB- family of pocket proteins (p110, p107, p130), E2F-family of transcription factors (heterodimers of E2F1-8 with DP1-2), cyclins (D and E-type), cyclin-dependent protein kinases (cdk4, cdk6) and cyclin-dependent kinase inhibitor CDKIs (p16Ink4a, p15Ink4b, p18Ink4c and p19Ink4d).
Teupser, "Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque," Atherosclerosis, vol.
Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.
TGF--dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex.
Lin, "Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-[beta]mediated induction of the CDK inhibitor p15Ink4B," Molecular Cell, vol.