CDKN2B

(redirected from p15-INK4b)

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
References in periodicals archive ?
The p15-Ink4B protein induces cell senescence because it forms a complex with cyclin-dependent kinase (CDK) 4 or CDK6 and prevents the activation of CDK kinases by cyclin D (Schwarze et al.
Upon binding directly to CDK4/6 and specific inhibitors of the cyclin D dependent kinases, p15-INK4b arrests cells in GI of the cell cycle, resulting in cellular senescence (Schwarze et al.