p-aminosalicylic acid

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Related to p-aminosalicylic acid: Sodium aminosalicylate

p-aminosalicylic acid

 (PAS) (PASA) [ah-me″no-sal-ĭ-sil´ik]
an analogue of p-aminobenzoic acid that inhibits folic acid synthesis in Mycobacterium tuberculosis, used in the treatment of tuberculosis, administered orally. In pharmacy it is officially called aminosalicylic acid. It enhances the potency of streptomycin and delays the development of bacilli resistant to streptomycin. Gastrointestinal irritation accompanied by anorexia, nausea, and vomiting may be reduced by administering the drug with food at mealtime.

p-a·mi·no·sal·i·cyl·ic ac·id (PAS, PASA),

(ă-mē'nō-sal-i-sil'ik as'id),
A bacteriostatic agent against tubercle bacilli, used as a second-line agent; potassium, sodium, and calcium salts have the same use.

p- aminosalicylic acid

/p- ami·no·sal·i·cyl·ic ac·id/ (PAS) (PASA) an analogue of aminobenzoic acid (PABA) with antibacterial properties; used to inhibit growth and multiplication of the tubercle bacillus..

p-aminosalicylic acid

a derivative of benzoic acid used in the treatment of tuberculosis. It enhances the potency of streptomycin and delays development of bacilli resistant to streptomycin. Also used to treat mycobacterial infections in fish. Abbreviated PAS, PASA.
References in periodicals archive ?
Of 50 MDR-TB isolates, 18 (18/50, 36%) showed resistance to ethionamide (ET), 13 (13/50, 26%) to d-cycloserine (DC), 11 (11/50, 22%) to ciprofloxacin (CP), 7 (7/50, 14%) to kanamycin (KA), 6 (6/50, 12%) to p-aminosalicylic acid (PA), and 5 (5/50, 10%) to amikacin (AM).
double dagger] Second-line drugs used for treatment of persons with confirmed MDR TB include ofloxacin, kanaymycin, ethionamide, p-aminosalicylic acid, and cycloserine or terizidone.
Susceptibility to first-line (streptomycin, isoniazid, rifampin, and ethambutol) and second-line (kana-mycin, ethionamide, capreomycin, cycloserine, p-aminosalicylic acid, and ofloxacin) drugs was determined by the proportion method on Middlebrook 7H10 agar.