p-aminosalicylic acid


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Related to p-aminosalicylic acid: Sodium aminosalicylate

p-aminosalicylic acid

 (PAS) (PASA) [ah-me″no-sal-ĭ-sil´ik]
an analogue of p-aminobenzoic acid that inhibits folic acid synthesis in Mycobacterium tuberculosis, used in the treatment of tuberculosis, administered orally. In pharmacy it is officially called aminosalicylic acid. It enhances the potency of streptomycin and delays the development of bacilli resistant to streptomycin. Gastrointestinal irritation accompanied by anorexia, nausea, and vomiting may be reduced by administering the drug with food at mealtime.

p-a·mi·no·sal·i·cyl·ic ac·id (PAS, PASA),

(ă-mē'nō-sal-i-sil'ik as'id),
A bacteriostatic agent against tubercle bacilli, used as a second-line agent; potassium, sodium, and calcium salts have the same use.
References in periodicals archive ?
([double dagger] Second-line drugs used for treatment of persons with confirmed MDR TB include ofloxacin, kanaymycin, ethionamide, p-aminosalicylic acid, and cycloserine or terizidone.
The second-line drugs included in the WHO Model List of Essential Medicines are amikacin, capreomycin, ciprofloxacin, cycloserine, ethionamide, kanamycin, levofloxacin, ofloxacin, p-aminosalicylic acid, and prothionamide (11).
Susceptibility to first-line (streptomycin, isoniazid, rifampin, and ethambutol) and second-line (kana-mycin, ethionamide, capreomycin, cycloserine, p-aminosalicylic acid, and ofloxacin) drugs was determined by the proportion method on Middlebrook 7H10 agar.