TT401 (LY2944876) is an oxyntomodulin
analogue that has dual agonist activity of the GLP-1 (Glucagon-Like Peptide-1) and glucagon receptors.
Bloom found a chemical, oxyntomodulin
, along with saline (sodium and water) and peptides, which is required to jumpstart the metabolism, contributing to weight loss.
As food enters your stomach it stimulates production of two hormones - peptide YY and oxyntomodulin
- that create a feeling of satiety," she explains.
increases the concentrations of insulin and glucose in plasma but does not affect ghrelin secretion in Holstein cattle under normal physiological conditions.
According to its inventor, Professor Stephen Bloom, a world-leading expert in obesity based at Imperial College London, the drug works by mimicking a gut hormone, oxyntomodulin
that the body makes when it has had enough to eat.
A Columbia University team reported last year in the Journal of Clinical Endocrinology & Metabolism that levels of a digestive hormone and appetite inhibitor called oxyntomodulin
are doubled in diabetic gastric bypass patients only one month after surgery, whereas similarly obese people who lost weight by dieting saw no increase.
is released by the L-cells of the small intestine after meals, and is believed to exert its biological effects by activating both the glucagon receptor and the GLP-1 receptor.
The drug, TKS1225, and related compounds are synthetic versions of a natural peptide--or protein fragment--found in the gastrointestinal system and called oxyntomodulin
Researchers have also discovered that topping up levels of oxyntomodulin
- a naturally acting digestive hormone - tricks the body into thinking it is full, thus reducing the appetite.
Obese patients taking part in a trial were given injections of oxyntomodulin
, a naturally occurring digestive hormone found in the small intestine.
This centres around a hormone called oxyntomodulin
that is naturally found in the body.
Their latest study involved patients being given injections of oxyntomodulin
- a naturally occurring digestive hormone found in the small intestine.