oxybutynin


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oxybutynin

 [ok″se-bu´tĭ-nin]
an anticholinergic and antimuscarinic having direct antispasmodic effects on smooth muscle; used orally as the chloride salt in treatment of uninhibited neurogenic bladder and reflex neurogenic bladder.

oxybutynin

Cystrin (UK), Kentera (UK), Oxytrol

oxycodone hydrochloride

Oxecta, OxyContin, Oxynorm (UK), Roxicodone, Supeudol (CA)

Pharmacologic class: Opioid agonist

Therapeutic class: Narcotic analgesic

Controlled substance schedule II

Pregnancy risk category B

FDA Box Warning

• Drug is opioid agonist and Schedule II controlled substance, with abuse potential similar to morphine. This potential must be considered when prescribing or dispensing drug.

• Extended-release tablets are indicated for managing moderate to severe pain when continuous, around-the-clock analgesia is needed for extended period of time. Extended-release tablets aren't intended for as-needed analgesia.

• Extended-release 80-mg tablets are for use only in opioid-tolerant patients. This strength may cause fatal respiratory depression when given to patients without previous opioid exposure.

• Instruct patients to swallow extended-release tablets whole. Caution them not to break, chew, or crush them, as this causes rapid release and absorption of potentially fatal dose.

Action

Unknown. Thought to interact with opioid receptor sites primarily in limbic system, thalamus, and spinal cord, blocking transmission of pain impulses.

Availability

Capsules (immediate-release): 5 mg

Solution (oral): 5 mg/5 ml

Tablets: 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg

Tablets (controlled-release): 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Indications and dosages

Moderate to severe pain

Adults: 5 mg P.O. q 6 hours p.r.n., increased gradually to 10 to 30 mg q 6 hours p.r.n.

Moderate or severe pain when continuous around-the-clock analgesia is needed

Adults: 10 mg P.O. (controlled-release) q 12 hours. For patients already taking opioids, use total oral oxycodone daily equianalgesic dosage and then round down to closest tablet strength. For breakthrough pain, give supplemental immediate-release doses.

Dosage adjustment

• Hepatic disease

• Renal impairment

• Debilitated or opioid-naive patients

Off-label uses

• Postherpetic neuralgia (controlled release form)

Contraindications

• Hypersensitivity to drug

• Paralytic ileus

• When opioids are contraindicated (as in respiratory depression, severe bronchial asthma, hypercarbia)

Precautions

Use cautiously in:

• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; urethral stricture; undiagnosed abdominal pain or prostatic hyperplasia; extensive burns; alcoholism

• history of substance abuse

• prolonged or high-dose therapy

• elderly or debilitated patients

• labor and delivery

• pregnant or breastfeeding patients

• children younger than age 18.

Administration

• Be aware that drug has high abuse potential.

• Know that controlled-release Oxy-Contin isn't indicated for p.r.n. pain control but is reserved for patients who need continuous, around-the-clock analgesia.

• Be aware that 80-mg controlled-release tablets are for opioid-tolerant patients only.

Never break, crush, or let patient chew controlled-release forms. Otherwise, rapid release and absorption of potentially fatal dose may occur.

• Give Oxecta tablets whole. Don't crush or dissolve tablets or administer by nasogastric, gastric, or other feeding tubes, because this may cause obstruction of feeding tubes.

• When discontinuing, taper dosage gradually to prevent withdrawal symptoms.

Adverse reactions

CNS: dizziness, asthenia, drowsiness, euphoria, light-headedness, insomnia, confusion, anxiety, twitching, abnormal dreams and thoughts

CV: orthostatic hypotension, circulatory depression, bradycardia, shock

GI: nausea, vomiting, constipation, diarrhea, ileus, abdominal pain, dyspepsia, gastritis, anorexia

GU: urinary retention

Respiratory: apnea, respiratory depression, respiratory arrest

Skin: pruritus, sweating

Other: chills, fever, hiccups, physical and psychological drug dependence

Interactions

Drug-drug. Antihistamines, sedative-hypnotics: additive CNS depression

Barbiturates, protease inhibitors: increased respiratory and CNS depression

Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients

Drug-diagnostic tests. Amylase, lipase: increased levels

Drug-behaviors. Alcohol use: additive CNS depression

Patient monitoring

Monitor vital signs and respiratory status. Withhold drug in significant respiratory or CNS depression.

• Assess patient's pain level frequently.

• Monitor bowel and bladder function.

• Assess patient for anxiety, twitching, and other CNS symptoms.

• Closely monitor head-trauma patient. Drug may increase ICP while masking signs and symptoms.

• Carefully assess patient with acute abdominal pain. Drug may obscure diagnosis.

• Stay alert for drug hoarding, tolerance, and dependence.

Patient teaching

Caution patient not to break, crush, chew, or dissolve controlled-release tablets. Warn him that doing so may cause rapid drug release and absorption (possibly fatal).

• Tell patient taking controlled-release form not to drive for 3 to 4 days after dosage increase, after consuming even a single alcoholic beverage, or if also taking antihistamines or other drugs that cause drowsiness.

• Tell patient to take Oxecta tablets whole.

Instruct patient to promptly report adverse reactions, especially difficulty breathing or slow pulse.

• Advise patient not to drink alcohol.

• Tell patient not to be alarmed if controlled-release tablets appear in stools; drug has already been absorbed.

• Advise ambulatory patient to change position slowly, to avoid dizziness from orthostatic hypotension.

• Instruct patient to consult prescriber before taking other drugs.

• Caution patient to avoid driving and other hazardous activities, because drug may cause drowsiness or dizziness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

oxybutynin

/oxy·bu·ty·nin/ (-bu´tĭ-nin) an anticholinergic having direct antispasmodic effect on smooth muscle; used as the chloride salt in the treatment of uninhibited or reflex neurogenic bladder.

oxybutynin

(ŏk′sē-byo͞ot′n-ĭn)
n.
An anticholinergic drug, C22H31NO3, used to treat incontinence and other urinary symptoms.

oxybutynin

Ditropan® Urology A spasmolytic anticholinergic GI and GU tract colic used to ↓ urge incontinence, overactive bladder, bladder Sx associated with neurogenic bladder–eg, frequency, urgency, dysuria, urinary leakage Contraindications Urinary retention, gastric retention, narrow-angle glaucoma Adverse effects Dry mouth, constipation, somnolence, diarrhea, blurred vision, dry eyes, dizziness, rhinitis. See Urge incontinence.

oxybutynin

An anticholinergic antispasmodic drug used to treat urinary urgency, frequency and incontinence and bed-wetting in children. Brand names are Cystrin, Ditropan and Lyrinel XL.

oxybutynin

an anticholinergic having direct antispasmodic effect on smooth muscle; used in the treatment of uninhibited neurogenic bladder and reflex neurogenic bladder.
References in periodicals archive ?
Recently, the effects of darifenacin and oxybutynin on cognitive measures were compared in a head-to-head clinical trial.
A more meaningful comparison would have been between extended-release oxybutynin and long-acting tolerodine.
The immediate-release (IR) (Ditropan[R]) and extended-release (ER) (Ditropan XL[R]) formulations of oxybutynin are currently the only pharmacological agents approved for the treatment of OAB in children in North America.
market sales for Oxybutynin Chloride Extended-Release Tablets, USP, which is used in the treatment of overactive bladder, were approximately $156 million for the twelve months ended August 31, 2016.
Human health company ACETO (NasdaqGS:ACET) stated on Monday that it plans to introduce Oxybutynin Chloride Extended-Release Tablets, USP in the market .
Data also support the use of oral oxybutynin for hyperhidrosis, he noted.
Those who took at least 10 milligrams (mg) per day of the tricyclic antidepressant doxepin (Sinequan[R]), 4 mg per day of the antihistamine diphenhydramine (Benadryl[R]), or 5 mg per day of the anticholinergic drug oxybutynin (Ditropan[R]) for more than three years were found to be at greater risk for dementia.
26, 2015 in JAMA Internal Medicine, people who took high doses of tricyclic antidepressants such as doxepin (Sinequan), diphenhydramine (Benadryl), older antihistamines such as chlorpheniramine (Chlor-Trimeton), or antimuscarinic drugs for bladder control, such as oxybutynin (Ditropan) for longer than three years were significantly more likely to develop dementia.
The study, published in journal Jama Internal Medicine, showed people were at higher risk if they took at least 10mg a day of antidepressant doxepin, 4mg a day of diphenhydramine or 5mg a day of bladder control drug oxybutynin for more than three years.
The US study by the University of Washington, in journal Jama Internal Medicine, showed people were at higher risk of dementia if they took at least 4mg diphenhydramine, 10mg of antidepressant doxepin, or 5mg of bladder control drug oxybutynin every day for three years