Methacholine, carbachol, bethanechol and oxotremorine
are the most known synthetic muscarinic agonists.
The involvement of cholinergic and noradrenergic systems in behavioral recovery following oxotremorine
treatment to chronically stressed rats.
The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine
enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance.
Atropine sulfate, scopolamine hydrochloride, oxotremorine
and pilocarpine sulfate were purchased from Sigma Chemical Co.
Another study showed that supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for eight weeks to 19-month old F344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters, including oxotremorine
enhancement of [K.sup.+]-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal 45[Ca.sup.2+] buffering in striatal synaptosomes, motor behavior performance on the rod walking and accelerated tasks, and Morris water maze performance.
In the pithed rat, DES (1 mg/kg, i.v.) inhibited negative inotropic (left ventricular dP/dt) and chronotropic effects caused by oxotremorine
, a nonselective muscarinic agonist (p < 0.05).
We bath-applied the mACh agonist oxotremorine and monitored local field potential (LFP) electrodes placed in the external plexiform layer of the OB to examine the effect of this mACh agonist on odor-evoked activity.
Oxotremorine (sesquifumarate salt) was mixed fresh daily in regular Ringer's solution and bath-applied at 100 [micro]M.
This was followed by studies of muscarinic agonists, such as bethanechol, arecoline and oxotremorine
, but adverse effects and low selectivity for the central nervous system limited their clinical use .
Moreover, in order to investigate whether Ninjin-yoei-to possesses a central cholinergic activity, we examined its effect on the tremors induced by oxotremorine
, a muscarinic acetylcholine [M.sub.1] receptor agonist, in mice.