oxotremorine

ox·o·trem·or·ine

(ok'sō-trem'ŏr-ēn),
An active metabolite of tremorine. Used as a pharmacologic tool for producing a parkinsonian tremor.
References in periodicals archive ?
Interactions of some cholinolytic anti-parkinson drugs with nicotine and oxotremorine on rat diaphragm.
The involvement of cholinergic and noradrenergic systems in behavioral recovery following oxotremorine treatment to chronically stressed rats.
1A]) and oxotremorine (a selective agonist of muscarinic receptors; Bonilla-Jaime, RetanaMarquez, & Velazquez-Moctezuma, 1998).
6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance.
Atropine sulfate, scopolamine hydrochloride, oxotremorine and pilocarpine sulfate were purchased from Sigma Chemical Co.
md 451 30 Desyat' Let Udmurtskoy ASSR Sovkhoz, Russia, 56[degrees]36, 53[degrees]15 31 1-(2-oxopyrrolidino)-4-pyrrolidino-2-butyne, OED oxotremorine 32 pull oneself up by one's (own) bootstraps, Chambers boot 34 cholecystojejunocholecystostomizes, see 417 452 30 K'o-tzu-lo-su-k'o-erh-k'o-tzu Tzu-chih-chou, China, 39[degrees]40, 76[degrees]10 33 not to halloo until one is out of the wood, OED halloo 2b 453 29 Stantsiya Volkovysk Tsentral'nyy, Belarus, 53[degrees]08, 24[degrees]25 35 ask me no questions and I'll tell you no lies, OED question I 6 d 36 laparohysterosalpingo-oophorectomized, from 1 .
6 gm of dried aqueous extract per kilogram of diet, respectively) fed for eight weeks to 19-month old F344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters, including oxotremorine enhancement of [K.
We bath-applied the mACh agonist oxotremorine and monitored local field potential (LFP) electrodes placed in the external plexiform layer of the OB to examine the effect of this mACh agonist on odor-evoked activity.
Oxotremorine (sesquifumarate salt) was mixed fresh daily in regular Ringer's solution and bath-applied at 100 [micro]M.
This was followed by studies of muscarinic agonists, such as bethanechol, arecoline and oxotremorine, but adverse effects and low selectivity for the central nervous system limited their clinical use [15].
Moreover, in order to investigate whether Ninjin-yoei-to possesses a central cholinergic activity, we examined its effect on the tremors induced by oxotremorine, a muscarinic acetylcholine [M.
Scopolamine hydrobromide, scopolamine methyl bromide and oxotremorine hydrochloride (Sigma Chemical Co.