oxitropium

oxitropium

An ANTICHOLINERGIC drug used from an inhaler to treat ASTHMA and chronic obstructive lung disease. A brand name is Oxivent.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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For chronic asthma, a Cochrane review found that short-acting anticholinergics (including ipratropium bromide, oxitropium bromide, and nebulised atropine methonitrate) provided an incremental benefit in peak flow versus placebo and no added benefit to SABAs; however, the authors acknowledge that some patient subgroups may derive some benefit from short-acting anticholinergics, including those intolerant to SABAs and those with nocturnal asthma, concurrent fixed airway obstruction, and asthma of a longer duration [15].
Oxygen desaturation and breathlessness during corridor walking in COPD: effect of oxitropium bromide.
Izumi, "The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease: a comparison of three different exercise tests," American Journal of Respiratory and Critical Care Medicine, vol.
Izumi, "Oxitropium bromide improves exercise performance in patients with COPD," Chest, vol.
Anticholinergics, such as ipratropium and oxitropium, decrease the amount of nasal secretions, but they have no effect on nasal obstruction.
In the present study, we tested the effects of the anticholinergic drug, oxitropium bromide (OTB), on lung function, exercise capacity, and exertional dyspnoea in elderly COPD patients (more than 75 years old) using a double-blind placebo-controlled study, in comparison with middle-aged patients (less than 65 years of age).
Data were analysed with Student's unpaired t test between oxitropium and placebo group.
We conclude that the inhaled anticholinergic drug, oxitropium bromide, produces useful improvements in dyspnoea and exercise capacity in both elderly and middle-aged patients with COPD.