Capillary electrophoretic analysis of oxindole
alkaloids from Un caria tomentosa.
They are divided into indole tetracyclic alkaloids (corynanthein, dihydrocorynanthein,hirsuthein,andhirsutine)oxindole
alkaloids (rhynchophylline, isorhynchophylline, corynoxein, isocorynoxein, rotundifolin, and isorotundifolin) indole pentacyclic alkaloids (akuamigine, augustine, augustolin, isoamalicin, and tetrahydroalstonin) and oxindole
alkaloids (speciophylline, mitraphylline, isomitraphylline, pteropodin, isopteropodin, and uncarin F), and glycoindole alkaloids (3a-dihydrocadambine and dolichantosin) (LAUS et al.
tomentosa s bark contains a series of secondary metabolites, such as oxindole
alkaloids and polyphenols (flavonoids, proanthocyanidins, tannins) and small concentrations of other secondary metabolites, such as quinovic acid glycosides, polyhydroxylated triterpenes and saponins (Laus, 2004; Aquino et al.
Direct synthesis of C3-mono-functionalized oxindoles
from N-unprotected 2-oxindole
and their antileishmanial activity," Bioorganic and Medicinal Chemistry, vol.
alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
50] values were calculated for different oxindole
The active principles thought to be responsible for these effects are pentacyclic oxindole
Chemistry: family producing iridoids and alkaloids (of indole & oxindole
types) notable amongst these being the tryptophanic alkaloids, rarely saponiferous, sometimes accumulating aluminum.
Zloh, "Insights into mechanism of anticancer activity of pentacyclic oxindole
alkaloids of Uncaria tomentosa by means of a computational reverse virtual screening and molecular docking approach," Monatsheftefur Chemie, vol.
a novel spiro oxindole
, welwitindolinone A isonitrile (59), five tetracyclic oxindoles
, and eight biogenetically related fischerindoles and hapalindoles.
These include 5 pentacyclic oxindole
alkaloids (P0As) and 4 tetracyclic oxindole