oxindole


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oxindole

(ŏk′sĭn-dōl)
Natural derivatives of tryptophan that are present in high concentrations in the brains of patients with hepatic encephalopathy. Chemicals from this class have sedative and antioxidant effects. Some evidence suggests oxindoles may be useful in the treatment of Alzheimer's dementia.
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References in periodicals archive ?
Su et al., "Novel oxindole based sensitizers: synthesis and application in dye-sensitized solar cells," Organic Letters, vol.
However, product 3l, the yield of 5-methyl-3,3-di(indolyl) oxindole, was excellent (Table 2, entry (12)).
reported an efficient sulfonated hyperbranched poly(arylene oxindole)s with 5-chloro-substituent group polymer acid catalyst (5-Cl-SHPAOs), and when it was applied for the catalytic conversion of cellulose into LA in [H.sub.2]O, the LA yield was up to 50% at 165[degrees]C for 5h, which was twice as high as unsubstituted SHPAOs (Table 6, entry 5) [352].
Rhynchophylline is an oxindole moiety that protects rat neuronal cells from the N-methyl-D-aspartate (NMDA)-induced neurotoxicity [48].
Nevertheless, other familiar metabolites reported such as indoxyl, oxindole, anthranilate, salicylate and gentisic acid, and hydroxyindole in similar researches were not observed [14].
They are divided into indole tetracyclic alkaloids (corynanthein, dihydrocorynanthein,hirsuthein,andhirsutine)oxindole alkaloids (rhynchophylline, isorhynchophylline, corynoxein, isocorynoxein, rotundifolin, and isorotundifolin) indole pentacyclic alkaloids (akuamigine, augustine, augustolin, isoamalicin, and tetrahydroalstonin) and oxindole alkaloids (speciophylline, mitraphylline, isomitraphylline, pteropodin, isopteropodin, and uncarin F), and glycoindole alkaloids (3a-dihydrocadambine and dolichantosin) (LAUS et al., 1997; FALKIEWICZ & LUKASIAK, 2001; LUNA-PALENCIA et al., 2013).
tomentosa s bark contains a series of secondary metabolites, such as oxindole alkaloids and polyphenols (flavonoids, proanthocyanidins, tannins) and small concentrations of other secondary metabolites, such as quinovic acid glycosides, polyhydroxylated triterpenes and saponins (Laus, 2004; Aquino et al., 1990, Aquino et al., 1989).
Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
Anticancer activity of the Uncaria tomentosa (Willd.) DC preparations with different oxindole alkaloid composition.