oxindole


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oxindole

(ŏk′sĭn-dōl)
Natural derivatives of tryptophan that are present in high concentrations in the brains of patients with hepatic encephalopathy. Chemicals from this class have sedative and antioxidant effects. Some evidence suggests oxindoles may be useful in the treatment of Alzheimer's dementia.
References in periodicals archive ?
They are divided into indole tetracyclic alkaloids (corynanthein, dihydrocorynanthein,hirsuthein,andhirsutine)oxindole alkaloids (rhynchophylline, isorhynchophylline, corynoxein, isocorynoxein, rotundifolin, and isorotundifolin) indole pentacyclic alkaloids (akuamigine, augustine, augustolin, isoamalicin, and tetrahydroalstonin) and oxindole alkaloids (speciophylline, mitraphylline, isomitraphylline, pteropodin, isopteropodin, and uncarin F), and glycoindole alkaloids (3a-dihydrocadambine and dolichantosin) (LAUS et al.
tomentosa s bark contains a series of secondary metabolites, such as oxindole alkaloids and polyphenols (flavonoids, proanthocyanidins, tannins) and small concentrations of other secondary metabolites, such as quinovic acid glycosides, polyhydroxylated triterpenes and saponins (Laus, 2004; Aquino et al.
Direct synthesis of C3-mono-functionalized oxindoles from N-unprotected 2-oxindole and their antileishmanial activity," Bioorganic and Medicinal Chemistry, vol.
Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
50] values were calculated for different oxindole alkaloid compositions.
The active principles thought to be responsible for these effects are pentacyclic oxindole alkaloids (POA).
Chemistry: family producing iridoids and alkaloids (of indole & oxindole types) notable amongst these being the tryptophanic alkaloids, rarely saponiferous, sometimes accumulating aluminum.
Uncaria tomentosa another ingredient present in ImmuneRich, also known as Cat's Claw contains oxindole alkaloids that have immune function enhancement properties.
Zloh, "Insights into mechanism of anticancer activity of pentacyclic oxindole alkaloids of Uncaria tomentosa by means of a computational reverse virtual screening and molecular docking approach," Monatsheftefur Chemie, vol.
a novel spiro oxindole, welwitindolinone A isonitrile (59), five tetracyclic oxindoles, and eight biogenetically related fischerindoles and hapalindoles.
These include 5 pentacyclic oxindole alkaloids (P0As) and 4 tetracyclic oxindole alkaloids (TOAs).