oxidized phospholipids

Fatty acids bound to a glycerol molecule containing a polar head group, which have been subjected to oxidation by free radicals or enzymes such as myeloperoxidase and lipoxygenase. They are proinflammatory and are believed to play an important part in the aetiology of atherosclerosis.

References in periodicals archive ?

Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events.

Cardiac Biomarkers: A Well Validated Clinical Management Tool

Miller et al., "Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins," Journal of Clinical Investigation, vol.

Elevated Levels of Plasma IgA Autoantibodies against Oxidized LDL Found in Proliferative Diabetic Retinopathy but Not in Nonproliferative Retinopathy

Spickett, "Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation," Free Radical Biology and Medicine, vol.

Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

HDL also prevents the formation of oxidized LDL, inactivates oxidized phospholipids, inhibits monocyteto-macrophage differentiation, and has anti-inflammatory effects on macrophage through inhibition of CD11 activation [7-9].

Sera from Visceral Leishmaniasis Patients Display Oxidative Activity and Affect the TNF-[alpha] Production by Macrophages In Vitro

Navab and colleagues (78) were the first to develop a novel and rapid cell-free assay to determine the ability of HDL to prevent the inactivation or formation of oxidized phospholipids. This fluorospectroscopic assay quantified the fluorescent signal generated by 2 oxidized phospholipids; oxLDL and oxidized L-[alpha]-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine.

The Changing Face of HDL and the Best Way to Measure It

[sup][27] A deﬁciency of PON1 enhanced atherosclerosis in hypercholesterolemic mice and was associated with an increase in oxidized phospholipids. [sup][28] In animals, apoJ levels increase in situations in which PON1 levels decrease.

Apolipoprotein J: A New Predictor and Therapeutic Target in Cardiovascular Disease?

Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease.

Lipoprotein (A) in clinical practice

Kinnunen, "Oxidized phospholipids as potential molecular targets for antimicrobial peptides," Biochimica et Biophysica Acta, vol.

Penetration of milk-derived antimicrobial peptides into phospholipid monolayers as model biomembranes

Tsimikas, "The role of oxidized phospholipids in atherosclerosis," Journal of Lipid Research, vol.

Formation and regulation of mitochondrial membranes

Recent studies show that oxidized phospholipids favor monocyte binding to endothelial cells, thus promoting diapedesis from the blood stream [51].

Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment

This particle's function remains largely uncertain; Lp(a) binds proinflammatory-oxidized phospholipids (11) and is a preferential carrier of oxidized phospholipids (ox-PL) in human plasma.

Aggregation of lipoprotein(a) to apolipoprotein A-I underlying HDL dysfunction as a major coronary risk factor/HDL disfonksiyonunun temelindekilipoprotein(a)'nin apolipoprotein A-I'e agregasyonu major bir koroner risk faktorudur

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