oxidized phospholipids

oxidized phospholipids

Fatty acids bound to a glycerol molecule containing a polar head group, which have been subjected to oxidation by free radicals or enzymes such as myeloperoxidase and lipoxygenase. They are proinflammatory and are believed to play an important part in the aetiology of atherosclerosis.
References in periodicals archive ?
Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events.
Miller et al., "Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins," Journal of Clinical Investigation, vol.
Spickett, "Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation," Free Radical Biology and Medicine, vol.
HDL also prevents the formation of oxidized LDL, inactivates oxidized phospholipids, inhibits monocyteto-macrophage differentiation, and has anti-inflammatory effects on macrophage through inhibition of CD11 activation [7-9].
Navab and colleagues (78) were the first to develop a novel and rapid cell-free assay to determine the ability of HDL to prevent the inactivation or formation of oxidized phospholipids. This fluorospectroscopic assay quantified the fluorescent signal generated by 2 oxidized phospholipids; oxLDL and oxidized L-[alpha]-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine.
[sup][27] A deficiency of PON1 enhanced atherosclerosis in hypercholesterolemic mice and was associated with an increase in oxidized phospholipids. [sup][28] In animals, apoJ levels increase in situations in which PON1 levels decrease.
Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease.
Kinnunen, "Oxidized phospholipids as potential molecular targets for antimicrobial peptides," Biochimica et Biophysica Acta, vol.
Tsimikas, "The role of oxidized phospholipids in atherosclerosis," Journal of Lipid Research, vol.
Recent studies show that oxidized phospholipids favor monocyte binding to endothelial cells, thus promoting diapedesis from the blood stream [51].
This particle's function remains largely uncertain; Lp(a) binds proinflammatory-oxidized phospholipids (11) and is a preferential carrier of oxidized phospholipids (ox-PL) in human plasma.