oxidized phospholipids

Fatty acids bound to a glycerol molecule containing a polar head group, which have been subjected to oxidation by free radicals or enzymes such as myeloperoxidase and lipoxygenase. They are proinflammatory and are believed to play an important part in the aetiology of atherosclerosis.

References in periodicals archive ?

Methodology for detecting and quantifying oxidized phospholipids is advancing rapidly, and will be continually refined as mass spectroscopy techniques improve.

The Changing Face of HDL and the Best Way to Measure It

In addition, reductions in low-density lipoprotein-cholesterol - (LDL-C) and pro-inflammatory oxidized phospholipids were observed, as well as a decrease in the inflammatory effects of white blood cells, which can initiate and accelerate cardiovascular disease.

United States : Akcea announces Publication in The Lancet of Clinical Results with Lp(a)-Lowering Drugs Designed to Treat Cardiovascular Disease

Evidence exists that HDL can reverse LDL oxidation by removing the oxidized phospholipids that make LDL harmful and lead to atherogenesis [42].

Serum Oxidized LDL Levels in Type 2 Diabetic Patients with Retinopathy in Mthatha Region of the Eastern Cape Province of South Africa

sup][27] A deﬁciency of PON1 enhanced atherosclerosis in hypercholesterolemic mice and was associated with an increase in oxidized phospholipids.

Apolipoprotein J: A New Predictor and Therapeutic Target in Cardiovascular Disease?

Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease.

Lipoprotein (A) in clinical practice

This particle's function remains largely uncertain; Lp(a) binds proinflammatory-oxidized phospholipids (11) and is a preferential carrier of oxidized phospholipids (ox-PL) in human plasma.

Aggregation of lipoprotein(a) to apolipoprotein A-I underlying HDL dysfunction as a major coronary risk factor/HDL disfonksiyonunun temelindekilipoprotein(a)'nin apolipoprotein A-I'e agregasyonu major bir koroner risk faktorudur

showed that human PON1 could inhibit LDL oxidation in vitro, prevents formation of oxidized LDL and protects phospholipids in HDL from oxidation by inactivating LDL-derived oxidized phospholipids (11).

Paraoxonase 1 activity in endocrine diseases/Endokrin hastaliklarda paraoksonaz 1 enzim aktivitesi

Potential involvement of biologically active oxidized phospholipids.

Relationship among plasma secretory phospholipase [A.sub.2], oxidized low density lipoprotein & paraoxonase activities in hypertensive subjects treated with angiotensin converting enzyme inhibitors

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that hydrolyzes oxidized phospholipids, releasing lysophosphatidylcholine, which has proinflammatory properties thought to be involved in the development of atherosclerosis and plaque rupture.

Lipoprotein-associated phospholipase A2 and risk of stroke

1 Recent studies have indicated that oxidized phospholipids can down-regulate the production of pro-inflammatory cytokines.

VBL Therapeutics Presents Positive Preclinical Data for VB-201 in Inflammatory Bowel Disease at Digestive Disease Week (DDW) 2012

Genetic elimination of autophagy resulted in massive accumulation of protein aggregates in stressed cells, elevation of Nrf2 target gene expression, and strikingly a significant rise in various oxidized species of phospholipids, implying that during homeostasis autophagy prevents accumulation of oxidized phospholipids, as well as overexpression of Nrf2 target genes in keratinocytes [57].

Dysfunction of Autophagy: A Possible Mechanism Involved in the Pathogenesis of Vitiligo by Breaking the Redox Balance of Melanocytes

Objective: MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools.

MASSTRPLAN: MASS Spectrometry TRaining network for Protein Lipid adduct ANalysis