on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events.
Miller et al., "Monoclonal autoantibodies specific for oxidized phospholipids
or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins," Journal of Clinical Investigation, vol.
Spickett, "Physiological effects of oxidized phospholipids
and their cellular signaling mechanisms in inflammation," Free Radical Biology and Medicine, vol.
HDL also prevents the formation of oxidized LDL, inactivates oxidized phospholipids
, inhibits monocyteto-macrophage differentiation, and has anti-inflammatory effects on macrophage through inhibition of CD11 activation [7-9].
Navab and colleagues (78) were the first to develop a novel and rapid cell-free assay to determine the ability of HDL to prevent the inactivation or formation of oxidized phospholipids
. This fluorospectroscopic assay quantified the fluorescent signal generated by 2 oxidized phospholipids
; oxLDL and oxidized L-[alpha]-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine.
[sup] A deﬁciency of PON1 enhanced atherosclerosis in hypercholesterolemic mice and was associated with an increase in oxidized phospholipids
. [sup] In animals, apoJ levels increase in situations in which PON1 levels decrease.
, Lp(a) lipoprotein, and coronary artery disease.
Kinnunen, "Oxidized phospholipids
as potential molecular targets for antimicrobial peptides," Biochimica et Biophysica Acta, vol.
Tsimikas, "The role of oxidized phospholipids
in atherosclerosis," Journal of Lipid Research, vol.
Recent studies show that oxidized phospholipids
favor monocyte binding to endothelial cells, thus promoting diapedesis from the blood stream .
This particle's function remains largely uncertain; Lp(a) binds proinflammatory-oxidized phospholipids (11) and is a preferential carrier of oxidized phospholipids
(ox-PL) in human plasma.