Oxidatively modified low density lipoprotein | definition of oxidatively modified low density lipoprotein by Medical dictionary
oxidatively modified low density lipoprotein
oxidatively modified low density lipoprotein A form of low-density lipoprotein that is modified in vivo and thought to play a key role in the development of atherosclerosis, given that its uptake by macrophages and smooth muscle cells leads to formation of foam cells, a critical step in atherosclerosis. Circulating OxLDL concentrations reflect the state of pathological atherosclerosis and are biochemical risk marker for coronary artery disease (CAD). OxLDL can be quantified by measuring malondialdehyde-modified LDL, which more accurately reflect CAD than surrogate markers such as cholesterol, HDL and LDL
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References in periodicals archive
Evidence for the presence of oxidatively modified low density lipoprotein
in atherosclerotic lesions of rabbit and man.
Simple and practical sandwich-type enzyme immunoassay for human oxidatively modified low density lipoprotein
using antioxidized phosphatidylcholine monoclonal antibody and antihuman apolipoprotein-B antibody.
Steinberg, "Oxidatively modified low density lipoproteins
: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis," Proceedings of the National Academy of Sciences of the United States of America, vol.