Calcabrini et al., "Creatine prevents the structural and functional damage to mitochondria in myogenic, oxidatively
stressed C2C12 cells and restores their differentiation capacity," Oxidative Medicine and Cellular Longevity, vol.
Complete release of (5'S)-8,5'-cyclo-2'-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively
induced DNA lesions.
Englander, "Brain capacity for repair of oxidatively
damaged DNA and preservation of neuronal function," Mechanisms of Ageing and Development, vol.
modified lipoproteins have reduced functional ability for reverse cholesterol transport, and thus formed lipid peroxides may influence activation, adhesion, infiltration, and differentiation of monocytes as well as the production of MPO and its oxidizing products.
While the 26S proteasome degrades polyubiquitinylated proteins, the 20S proteasome by itself seems to be sufficient to degrade nonubiquitinylated oxidatively
modified proteins in an ATPindependent manner; however, the exact mechanism is still unclear [13,18, 19].
It was found that extracellular oxidatively
modified high density lipoprotein induces ROS level in human-derived macrophage lineage cells, which is associated with macrophage death .
The production of biopyrrins increases in oxidatively
insulted rats subjected to endotoxin treatment (4) and ischemia-reperfusion (5).
The other two studies measured circulating nucleic acids, oxidatively
changed tRNA , and cell-free double-stranded DNA .
The high levels of oxidative stress created as a result of this process ultimately damage the DNA in the sperm nucleus; indeed, DNA damage in the male germ line appears to be predominantly induced oxidatively
, reflecting the vulnerability of these cells to such stress.
(2) Free radicals are continuously produced in the body but they are scavenged by antioxidant defense systems that also prevent the oxidatively
damaged molecules from getting accumulated.
In the presence of POD, hydrogen peroxide that was produced in the previous step is coupled oxidatively
to phenol and 4-aminoantipyrine to yield a dye called quinonimine that is red in color.