oxidative phosphorylation


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phosphorylation

 [fos″for-ĭ-la´shun]
the process of introducing a phosphate group into an organic molecule.
oxidative phosphorylation the final common pathway of aerobic energy metabolism in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor. It occurs in mitochondria.

ox·i·da·tive phos·phor·y·la·tion

formation of high-energy phosphoric bonds (for example, in pyrophosphates) from the energy released by the flow of electrons to O2 and the dehydrogenation (i.e., oxidation) of various substrates, most notably isocitric acid, α-ketoglutaric acid, succinic acid, and malic acid in the tricarboxylic acid cycle.

oxidative phosphorylation

n.
The process in cell metabolism by which respiratory enzymes in the mitochondria synthesize ATP from ADP and inorganic phosphate during the oxidation of NADH by molecular oxygen.

oxidative phosphorylation

[ok′sidā′tiv]
an ATP-generating process in which oxygen serves as the final electron acceptor. The process occurs in mitochondria and is the major source of adenosine triphosphate generation in aerobic organisms.

oxidative phosphorylation

The formation of ATP within mitochondria using energy derived from the electron transport chain

ox·i·da·tive phos·phor·y·la·tion

(ok'si-dā'tiv fos'fōr-i-lā'shŭn)
Formation of high energy phosphoric bonds from the energy released by the dehydrogenation (i.e., oxidation) of various substrates.

oxidative phosphorylation

The process of cellular respiration occurring within the MITOCHONDRIA and responsible for the production of adenosine triphosphate (ATP). In this process energy derived from the oxidation of hydrogen, to form water, is transferred to ATP.

oxidative phosphorylation

a process that takes place in the ELECTRON TRANSPORT SYSTEM of aerobic respiration, in which ATP molecules are synthesized from ADP and inorganic phosphate. The process is the major means by which aerobic organisms obtain their energy from foodstuffs.

oxidative phosphorylation

oxidation of products of carbohydrate, fat, protein and alcohol metabolism to carbon dioxide and water with formation of ATP from ADP and inorganic phosphate (Pi), associated with the transfer of electrons from substrate via coenzymes to oxygen, taking place in mitochondria. See also adenosine mono-, di- and triphosphates (AMP, ADP, ATP).

oxidative

pertaining to or emanating from oxidation.

oxidative deamination
oxidative breakdown of amino acids; specialized enzyme systems carry out the process, e.g. d-amino oxidase.
oxidative metabolism
enzymic pathways leading to the addition of oxygen or removal of hydrogen from intermediates in the pathway.
oxidative phosphorylation
the mitochondrial process by which the free energy from the oxidation of intracellular substrates is made available in the form of ATP for cellular endergonic processes.

phosphorylation

the process of introducing a phosphate group into an organic molecule.

oxidative phosphorylation
the final common oxidative pathway in which high-energy phosphate bonds are formed by phosphorylation of ADP to ATP by harnessing by F0,F1-ATPase of the proton motive force generated from pumping of protons from the matrix of mitochondria across the inner mitochondrial membrane to the intermembrance space and is coupled with the transfer of electrons along a chain of carrier proteins with molecular oxygen as the final acceptor.
References in periodicals archive ?
Toward a class-independent quantitative structure--activity relationship model for uncou plers of oxidative phosphorylation.
Approaches to finding the molecular basis of mitochondrial oxidative phosphorylation disorders.
ATP synthesis is usually a mitochondrial function and is subserved by mitochondrial oxidative phosphorylation.
The introduction of this non-Mendelian inheritance pattern led to a discussion of mitochondrial genetics, with an emphasis on the contribution of mtDNA to oxidative phosphorylation and the important harmful consequences of mtDNA mutations on this process.
Generation of ROS in mitochondria is therefore a byproduct of cell respiration, due to electron leakage in the electron trans-port chain (ETC) during oxidative phosphorylation (13) (Fig.
Oxidative phosphorylation involves the production of ATP from ADP and phosphate by harnessing the energy released as electrons are transferred during a series of oxidation-reduction reactions at the cellular level.
After the first few seconds are over, anaerobic glycolysis and aerobic oxidative phosphorylation become the source of ATE The reversible equilibrium takes place and phosphocreatine is replenished again until the ATP stores become depleted.
The coupling of these two functions is the ensuing Mitochondrial Oxidative Phosphorylation, which in the brain has to work optimally to produce the maximum amount of energy from a glucose molecule.
Prolonged impairment in oxidative phosphorylation activity causes accumulation of lactate and unprocessed glucose.
2]) is vital for life; its major role in normal metabolism is oxidative phosphorylation.
In fact, increased production of free radicals during muscle activity is results of oxidative phosphorylation in mitochondrial, synthesis of eicosanoid and by some enzymatic reactions (primarily xanthin oxidase) and these processes lead to oxidative modification of proteins, including the antioxidant enzymes, and at the same time reducing their protective care which results in pro-antioxidants imbalance.