Thiamine is a component of thiamine pyrophosphate, which participates in oxidative decarboxylation
of pyruvic acid and [alpha]-ketoglutaric acid.
Effects of phenolic compounds on adventitious root formation and oxidative decarboxylation
of applied indoleacetic acid in Malus Jork 9'.
Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumour and carries poor prognosis despite recent advances in management.1 A comprehensive genetic analysis of protein codes has found recurrent mutations in isocitrate dehydrogenase 1 (IDH1) gene in 12% of GBM.2 IDH1 catalyzes the oxidative decarboxylation
of isocitrate to ?-ketoglutarate which protects cells in situation of oxidative stress.3 The recurrent somatic mutation involves codon 132 of IDH1 gene on chromosome 2q33 and is implicated in determining the prognosis.2 Herein we have reviewed the evidence on the effect of IDH 1 mutation on the survival of patients with GBM.
The oxidative decarboxylation of pyruvate catalyzed by pyruvate ferredoxin oxidoreductase (POR) leads to the production of acetylcoenzyme A, which is subsequently converted to acetate as anend productvia the enzyme acetyl-coenzyme Asynthetase [4-6].
POR is a ferredoxin-dependent iron-sulfur protein catalyzing the reversible oxidative decarboxylation of pyruvate to acetyl-coenzyme A and C[O.sub.2] with the sequential transfer of the reducing equivalents to ferredoxin, which can be used toward the reduction of the sulfate, [N.sub.2], or protons [24-26].
This subsequently causes reduction of the oxidative decarboxylation
of pyruvate resulting in decreased utilization of oxygen and glucose.
The glucose so produced or the glucose absorbed from diet undergoes a series of reactions through anaerobic glycolytic pathway in the tissues to produce pyruvic acid and then lactic acid or the pyruvic acid undergoes oxidative decarboxylation
to form acetyl Co-A which is channelised into aerobic Kreb's cycle, which in its cycle generates reduced nucleotides (NADH and FAD) for the ultimate generation of biological currency, ATP through electron transport system.